Disorders of Localized Inflammation in Wound Healing
Wound healing is a conserved, multistep physiological process that relies on a balanced equilibrium between neutralization of the causative agent and restoration of native tissue structure and function. An imbalance at any step can quickly escalate into a
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omplex Systems and Computational Biology Approaches to Acute Inflammation A Framework for Model-based Precision Medicine Second Edition
Complex Systems and Computational Biology Approaches to Acute Inflammation
Yoram Vodovotz • Gary An Editors
Complex Systems and Computational Biology Approaches to Acute Inflammation A Framework for Model-based Precision Medicine Second Edition
Editors Yoram Vodovotz Department of Surgery University of Pittsburgh Pittsburgh, PA, USA Center for Inflammation and Regeneration Modeling McGowan Institute for Regenerative, Medicine University of Pittsburgh Pittsburgh, PA, USA
Gary An Department of Surgery University of Vermont Burlington, VT, USA Department of Computational and Systems Biology, University of Pittsburgh Pittsburgh, PA, USA
ISBN 978-3-030-56509-1 ISBN 978-3-030-56510-7 (eBook) https://doi.org/10.1007/978-3-030-56510-7 © Springer Nature Switzerland AG 2013, 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
We are now standing at the cusp of systems-based understanding of the processes that underlie, drive, and control the acute inflammatory response. Based on decades of painstaking progress, mostly driven by the reductionist methods that have served science well for hundreds of years, this new systems approach is poised to redefine how we approach diagnosis and therapy for sepsis/infection, trauma, and wound healing. The development of systems and computational biology over the past decade has brought a new understanding, new methods, and new terminology to the forefront of the biomedical enterprise. These new tools and new understanding have begun to yield insights into basic biological mechanisms. What has lagged has been a
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