Distinct Serum and Vitreous Inflammation-Related Factor Profiles in Patients with Proliferative Vitreoretinopathy
- PDF / 521,093 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 63 Downloads / 148 Views
CASE SERIES
Distinct Serum and Vitreous Inflammation-Related Factor Profiles in Patients with Proliferative Vitreoretinopathy Yao Ni . Yingyan Qin . Zijing Huang . Fangyuan Liu . Shaochong Zhang . Zhaotian Zhang
Received: March 6, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Proliferative vitreoretinopathy (PVR), which is regulated by growth factors and cytokines, is the leading cause of failure in vitreoretinal surgery. In this study, we aimed to investigate the role of the human serum and vitreous inflammation-related factors in the development of proliferative vitreoretinopathy (PVR). Methods: Blood and vitreous samples were obtained from patients undergoing pars plana vitrectomy. Inflammation-related factors were detected using an immunology multiplex assay on a LuminexÒ xMAPÒ platform. Patients with PVR and rhegmatogenous retinal detachment (RRD) were compared with macular hole (MH) Yao Ni and Yingyan Qin contributed equally to this study.
Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.12024765. Y. Ni Y. Qin F. Liu S. Zhang (&) Z. Zhang (&) State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China e-mail: [email protected]. Zhang e-mail: [email protected] Z. Huang Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China
or epiretinal membrane (ERM) patients without any other ocular or systemic disease. Results: Thirty-six serum samples and 34 vitreous samples were obtained. Thirty-one different growth factors and cytokines were detected in serum samples. However, none of the circulating growth factors and cytokines were found to be different from the controls. Ten different growth factors and cytokines were measured in the vitreous samples. The concentration levels of PDGF-AA, TGF-a, VEGF, IL-6, IL-8, and TNFb were found to have significantly increased in the vitreous of PVR patients. Conclusion: Our study found that none of the circulating inflammation-related factors were changed in PVR or RRD patients, indicating the absence of a system inflammatory biomarkers to predict the development of proliferative vitreoretinopathy. As a supplement to previous research, the concentrations of PDGF-AA, TGFa, VEGF, IL-6, IL-8, and TNFb were significantly upregulated in the vitreous of PVR patients. These factors should be considered for preventing PVR. Keywords: Cytokine; Inflammation; Ophthalmology; Proliferative vitreoretinopathy; Rhegmatogenous retinal detachment; Serum; Vitreous
Adv Ther
Key Summary Points Proliferative vitreoretinopathy (PVR), which is regulated by growth factors and cytokines, is the leading cause of failure in vitreoretinal surgery. Therefore, new therapeutic targets or early detection and monitoring of biomarkers are needed to prevent PVR. While the role of local retinal inflammation in the development of PVR is documented, we aimed to assess not only the cytokine profile in the v
Data Loading...
