Distributed, High-Performance and Grid Computing in Computational Biology

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Werner Dubitzky Assaf Schuster Peter M.A. Sloot Michael Schroeder Mathilde Romberg (Eds.)

Distributed, High-Performance and Grid Computing in Computational Biology International Workshop, GCCB 2006 Eilat, Israel, January 21, 2007 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Werner Dubitzky Mathilde Romberg University of Ulster, School of Biomedial Sciences, Coleraine, UK E-mail: {w.dubitzky, me.romberg}@ulster.ac.uk Assaf Schuster Technion – Israel Institute of Technology, Haifa, Israel E-mail: [email protected] Peter M.A. Sloot University of Amsterdam, Section of Computational Science, The Netherlands E-mail: [email protected] Michael Schroeder Biotec, Dresden University of Technology, Germany E-mail: [email protected]

Library of Congress Control Number: 2006939917

CR Subject Classification (1998): F.1, F.2, J.3, D.1, D.2, D.4, C.2, C.4, H.4 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-540-69841-8 Springer Berlin Heidelberg New York 978-3-540-69841-8 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2007 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 11976158 06/3142 543210

Preface

This volume of the Springer Lecture Notes in Computer Science series contains the contributions presented at the International Workshop on Distributed, HighPerformance and Grid Computing in Computational Biology 2006 (GCCB 2006) held in Eilat, January 21, 2007 in conjunction with the fifth European Conference on Computational Biology (ECCB 2006). Modern computational biology and bioinformatics are characterized by large and complex-structured data and by applications requiring considerable computing resources, such as processing units, storage elements and software programs. In addition, these disciplines are intrinsically geographically distributed in terms of their instru