Advances in Computational Biology

Proceedings of The 2009 International Conference on Bioinformatics and Computational Biology in Las Vegas, NV, July 13-16, 2009. Recent advances in Computational Biology are covered through a variety of topics. Both inward research (core areas of computat

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Advances in Experimental Medicine and Biology Editorial Board: Irun R. Cohen, The Weizmann Institute of Science Abel Lajtha, N.S. Kline Institute for Psychiatric Research John D. Lambris, University of Pennsylvania Rodolfo Paoletti, University of Milan

Volumes published in the series Volume 672 BIOSURFACTANTS Edited by Ramkrishna Sen Volume 673 MODELLING PARASITE TRANSMISSION AND CONTROL Edited by Edwin Michael and Robert C. Spear Volume 674 INTEGRINS AND ION CHANNELS: MOLECULAR COMPLEXES AND SIGNALING Edited by Andrea Becchetti and Annarosa Arcangeli Volume 675 RECENT ADVANCES IN PHOTOTROPHIC PROKARYOTES Edited by Patrick C. Hallenbeck Volume 676 POLYPLOIDIZATION AND CANCER Edited by Randy Y.C. Poon Volume 677 PROTEINS: MEMBRANE BINDING AND PORE FORMATION Edited by Gregor Anderluh and Jeremy Lakey Volume 678 CHEMO FOG: CANCER CHEMOTHERAPY-RELATED COGNITIVE IMPAIRMENT Edited by Robert B. Raffa and Ronald J. Tallarida Volume 679 MIPS AND THEIR ROLE IN THE EXCHANGE OF METALLOIDS Edited by Thomas P. Jahn and Gerd P. Bienert Volume 680 ADVANCES IN COMPUTATIONAL BIOLOGY Edited by Hamid R. Arabnia

Hamid R. Arabnia Editor

Advances in Computational Biology

Editor Hamid R. Arabnia University of Georgia Dept. Computer Science 30602-7404 Athens Georgia 415 Boyd Graduate Studies Research Ctr. USA

ISSN 0065-2598 ISBN 978-1-4419-5912-6 e-ISBN 978-1-4419-5913-3 DOI 10.1007/978-1-4419-5913-3 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2010934907 # Springer ScienceþBusiness Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

It gives us great pleasure to introduce the book entitled “Advances in Computational Biology." The book is composed of a collection of papers received in response to an announcement that was widely distributed to academicians and practitioners in the broad area of computational b