Do microvascular changes occur preceding neural impairment in early-stage diabetic retinopathy? Evidence based on the op
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ORIGINAL ARTICLE
Do microvascular changes occur preceding neural impairment in earlystage diabetic retinopathy? Evidence based on the optic nerve head using optical coherence tomography angiography Zijing Li1,2 · Xin Wen1,2 · Peng Zeng1,2 · Yunru Liao1,2 · Shuxian Fan1,2 · Yichi Zhang1,2 · Yuanjun Li1,2 · Jianhui Xiao1,2 · Yuqing Lan1,2 Received: 5 December 2018 / Accepted: 5 January 2019 © Springer-Verlag Italia S.r.l., part of Springer Nature 2019
Abstract Aims To evaluate the microvascular and neural differences of the optic nerve head (ONH) between type 2 diabetes mellitus (T2DM) subjects and controls. Methods This was a cross-sectional observational study. One hundred and eight eyes of 108 T2DM subjects with or without diabetic retinopathy (DR) (54 preclinical DR and 54 mild-to-moderate DR) were included. Fifty-two eyes of 52 healthy subjects were included as controls. The 4.5-mm Angio Disc scan mode and the ganglion cell complex scan mode were performed with all participants using AngioVue software 2.0 of the optical coherence tomography angiography (OCTA) device. Results Regarding ONH radial peripapillary capillary (RPC) density, the peripapillary region was mainly significantly reduced in the No-DR (NDR) group. Moreover, the RPC density of the peripapillary region and the inside optic disc area were significantly reduced in the non-proliferative DR (NPDR) group. When compared to the controls, significantly reduced peripapillary capillary density in six sections was observed in the NPDR group. However, reduced density was observed in only two sections in the NDR group. The NPDR group had significantly increased focal loss volume (FLV) and reduced peripapillary RNFL thickness in the inferior nasal section compared to those in the controls, but similar changes were not observed in the NDR group. A regression model identified RPCs inside the optic disc as a significant parameter in earlystage DR detection. In the NPDR group, BCVA showed a significantly negative correlation with RPCs inside the optic disc and a significantly positive correlation with FLV. Conclusions OCTA findings of the ONH area may provide evidence that microvascular changes occur preceding neural impairment in early-stage DR. However, further researches are still needed to support the statement. Reduced ONH perfusion inside the optic disc may be one of the crucial biomarkers in early-stage DR detection and is a possible sensitive visual acuity predictor in early-stage DR subjects. With the ONH mode, OCTA may be a more promising tool in DR screening. Keywords Optical coherence tomography angiography · Diabetic retinopathy · Optic nerve head · Microvascular changes · Neural impairment Managed By Antonio Secchi. Zijing Li and Xin Wen contributed equally to the manuscript as first authors. * Yuqing Lan [email protected] 1
Department of Ophthalmology, Sun Yat‑sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510000, People’s Republic of China
Guangdong Provincial Key Laboratory of Malignant Tumor
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