Do obese patients with primary knee osteoarthritis benefit from a single bout of moderate intensity aerobic exercise?
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(2020) 47:27
Egyptian Rheumatology and Rehabilitation
RESEARCH
Open Access
Do obese patients with primary knee osteoarthritis benefit from a single bout of moderate intensity aerobic exercise? Reham M. Shaat1*, Tamer O. Elsaid1, Aymen EL Baz2, Rehan Monir2,3 and Shereen Aly Machaly1
Abstract Background: Obesity and osteoarthritis are often concomitant. Both are accompanied by oxidative stress and stimulated inflammatory response. Exercise is considered a substantial treatment in rehabilitation of both conditions. Yet most of literature reported the benefits of regular exercising, while there is paucity about the effects of single low to moderate exercise session. This study aimed to investigate the possible potential effects of a single bout of moderate exercise in obese middle-aged individuals with knee osteoarthritis (KOA). Results: Score of pain and Western Ontario and Mc-Master University (WOMAC) had been improved 24 h after exercise. Glutathione reductase (GR) activity increased post-exercise but decreased the next 24 h though remained higher than baseline. Blood glucose level was reduced post-exercise whereas blood lipids still uninfluenced by exercise. Markers of inflammation remained unchanged after exercise session. Conclusion: A single bout moderate-intensity aerobic exercise is effective in improving pain and antioxidant activity among middle-aged obese patients with primary knee OA. Single bout of mild to moderate exercise may help in treatment of obese patients with KOA. Trial registration: Clinical Trials.gov Identifier: NCT03927339 Keywords: Obesity, Knee osteoarthritis, Single aerobic exercise session, Glutathione reductase, Oxidative stress
Background Dramatically, worldwide obesity incidence has increased throughout the recent decades. Obesity and its accompanying disorders like KOA now represent significant health impacts in both developed and developing countries [1]. KOA is a clinical multifactorial disorder with several etiologies and different risk factors that probably contribute to its manifestations, and of them is obesity and inflammation, the mostly blamed and constitute the highest associated disorders with the disease [2]. Increased oxidative stress seems to be an important component of both obesity and osteoarthritis (OA) and * Correspondence: [email protected]; [email protected]; [email protected] 1 Faculty of Medicine, Department of Rheumatology and Rehabilitation, Mansoura University, Elgomhoria St, Mansoura, Egypt Full list of author information is available at the end of the article
may formulate an important track joining obesity with the elevated incidence of OA. In obesity, as well as in OA, the cellular antioxidant capability is insufficient for detoxifying the reactive oxygen species (ROS), with the resulting oxidative stress that may cause damage of cellular enzymes and organelles, resulting in the development of insulin resistance, degrading components located extracellular such as collagens and proteoglycans, and additionally, increasing the susceptibilit
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