Dog Mesenchymal Stem Cell Basic Research and Potential Applications

Mesenchymal stem cells (MSCs) being available in numerous adult tissues and foetal membranes have been harvested from almost all these sources in dog. Due to the presence of miniscule number of MSCs in these tissues, culture expansion followed by their ch

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nchymal Stem Cell in Veterinary Sciences

Mesenchymal Stem Cell in Veterinary Sciences

Mudasir Bashir Gugjoo  •  Amar Pal Editors

Mesenchymal Stem Cell in Veterinary Sciences

Editors Mudasir Bashir Gugjoo Division of Veterinary Clinical Complex FVSc & AH, SKUAST-Kashmir Jammu and Kashmir, India

Amar Pal Division of Surgery Indian Veterinary Research Institute Izatnagar, India

ISBN 978-981-15-6036-1    ISBN 978-981-15-6037-8 (eBook) https://doi.org/10.1007/978-981-15-6037-8 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Preface

Tissues and/or organs are constituted by building blocks, the cells. These cells are either undifferentiated stem cells or differentiated tissue-specific cells. The miniscule number of available undifferentiated stem cells act as a reserve to maintain normal cell turn-over and thereby, tissue homeostasis. The differentiated cells perform the tissue-specific function. For a substantial and effective cellular therapy, the cells have to be sufficient in quantity and compatible with the recipient immune system, besides expressing as per the tissue requirements. The differentiated cells taken from the particular tissue source often are limited in number, have little or no proliferation potential and elicit the immune response in the recipient upon allogeneic or xenogeneic transplantation. Contrarily, the stem cells especially mesenchymal stem cells (MSCs) can be harvested from almost all the body tissue sources including the foetal membranes and have good proliferation and trans-­differentiation