Drug Discovery in Africa Impacts of Genomics, Natural Products, Trad
Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development i
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Kelly Chibale • Mike Davies-Coleman • Collen Masimirembwa Editors
Drug Discovery in Africa Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs
Editors Kelly Chibale Dept. of Chemistry University of Cape Town Rondebosch South Africa
Mike Davies-Coleman Department of Chemistry Rhodes University Grahamstown South Africa
Collen Masimirembwa African Institute of Biomedical Science and Technology Harare Zimbabwe
ISBN 978-3-642-28174-7 ISBN 978-3-642-28175-4 (eBook) DOI 10.1007/978-3-642-28175-4 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012938653 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: # MShep2 Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Professor Johnson Jato. A Tribute On June 27, 2012, we were deeply saddened to hear of the passing in his sleep of our dear friend and colleague, Johnson Jato, at his home in Yaounde, Cameroon. In Chap. 2, we discuss some of the significant and novel drug leads discovered from African biodiversity in the US National Cancer Institute (NCI) program. In launching the NCI plant collection program in Cameroon in 1986 through a contract with Missouri Botanical Garden (MBG), P
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