Drug-Induced Fibrosing Lesions
A number of medications have been linked to an increased risk of developing fibrosing disorders affecting a single or multiple organs. Many reports are based on single cases or limited case series, but over time case-controlled studies have been conducted
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Augusto Vaglio Editor
Systemic Fibroinflammatory Disorders
Rare Diseases of the Immune System Series Editors: Lorenzo Emmi Domenico Prisco Editorial Board: Systemic Vasculitis L. Emmi C. Salvarani R.A. Sinico
Primary Immunodeficiency A. Plebani C.T. Baldari M.M. D’Elios
Autoimmune Disease P. L. Meroni D. Roccatello M. Matucci Cerinic L. Emmi
Systemic Fibroinflammatory Disorders A. Vaglio
Autoinflammatory Syndromes M. Gattorno F. De Benedetti R. Cimaz
Passaggio, Laura Maddii Emmi (private collection)
Augusto Vaglio Editor
Systemic Fibroinflammatory Disorders
Editor Augusto Vaglio Department of Nephrology University Hospital Parma Italy
ISSN 2282-6505 ISSN 2283-6403 (electronic) Rare Diseases of the Immune System ISBN 978-3-319-41347-1 ISBN 978-3-319-41349-5 (eBook) DOI 10.1007/978-3-319-41349-5 Library of Congress Control Number: 2016963614 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To my sweet family
Contents
1 Genetics of Fibroinflammatory Disorders������������������������������������������������ 1 Davide Martorana, Francesco Bonatti, and Javier Martin 2 Basic Mechanisms Linking Inflammation and Fibrosis������������������������ 17 Carlo Chizzolini 3 The Pathology of Systemic Fibroinflammatory Disorders�������������������� 33 Domenico Corradi and Maria Nicastro 4 IgG4-Related Disease: A Prototypical Fibroinflammatory Disease. Overview on Clinical and Therapeutic Aspects����������������������� 53 Mikael Ebbo, Aurélie Grados, and Nicolas Schleinitz 5 Pathophysiology of IgG4-Related Disease ���������������������������������������������� 71 Jochen Zwerina 6 Autoimmune (IgG4-Related) Pancreatitis ���������������������������������������������� 81 Luca Frulloni an
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