Drug Resistance in Leishmania Parasites Consequences, Molecular Mech
Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon. This volume is the second edition of a well-received book that provides a comprehensive update on
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rug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments Second Edition
Drug Resistance in Leishmania Parasites
Alicia Ponte-Sucre • Maritza Padrón-Nieves Editors
Drug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments Second Edition
Editors Alicia Ponte-Sucre Institute of Experimental Medicine Universidad Central de Venezuela Caracas, Venezuela
Maritza Padrón-Nieves Escuela Luis Razetti Fac de Medicine Universidad Central de Venezuela Caracas, Venezuela
ISBN 978-3-319-74185-7 ISBN 978-3-319-74186-4 https://doi.org/10.1007/978-3-319-74186-4
(eBook)
Library of Congress Control Number: 2018942230 # Springer International Publishing AG, part of Springer Nature 2013, 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To our students, their curiosity inspires us to continue in our path of searching and learning about this ancient disease. To the patients suffering leishmaniasis, our best partners to understand and fight against this devastating disease.
Foreword
The year 2013 saw the publication of the first edition of the volume Drug Resistance in Leishmania Parasites, edited by Alicia Ponte-Sucre. A brand-new edition is now available in which ten of the chapters have been drastically updated, two chapters slightly revised, and two entirely new chapters added. This updated version is timely, because recent years have revealed important new information about drug resistance in Leishmania. Furthermore, major efforts are being made to control this problem. Knowledge has increased by studies of the mechanisms by which resistance is generated and by epidemiological and population genomic research on how drug re
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