Drug Transporters in Drug Disposition, Effects and Toxicity
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and ef
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Xiaodong Liu Guoyu Pan Editors
Drug Transporters in Drug Disposition, Effects and Toxicity
Advances in Experimental Medicine and Biology Volume 1141
Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Xiaodong Liu • Guoyu Pan Editors
Drug Transporters in Drug Disposition, Effects and Toxicity
Editors Xiaodong Liu School of Pharmacy China Pharmaceutical University Nanjing, Jiangsu, China
Guoyu Pan Shanghai Institute of Materia Medica Chinese Academy of Science Shanghai, Shanghai, China
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-13-7646-7 ISBN 978-981-13-7647-4 (eBook) https://doi.org/10.1007/978-981-13-7647-4 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Drug transporters are well-recognized determinants of drug disposition and effects/ toxicity. These are divided into solute carrier (SLC) family and ATP-binding cassette (ABC) family. Functionally, they mediate drug uptake into cells and export drugs out of cells, respectively. Each transporter has a specific pattern of tissue expression. Transporters expressed in the small intestine, liver, and kidney are very important for drug disposition and drug-drug interactions, while transporters expressed i
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