Drugs Used for Controlled Hypotension
The aims of controlled hypotension in neurosurgical practice are to decrease blood loss during surgery, to provide a dry surgical field and to diminish the risk of intraoperative aneurysm rupture. The benefits of controlled hypotension must be discussed i
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The Effects of Anaesthetics upon
Cerebral Circulation and Metabolism Experimental and Clinical Studies
Springer-Verlag Wien GmbH
J6rn Bo Madsen, M.D. Department of Anaesthesiology, Copenhagen County Hospital at Hvidovre, Hvidovre, Denmark Georg Emil Cold, M.D. Department of Neuroanaesthesiology, A.rhus Kommunehospital, A.rhus, Denmark
With 14 Figures
Product Liability: The publisher can give no guarantee for information about drug dosage and application theroof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. This work is subjected to copyright AII rights are reserved, whether the whole or part of the material is concemed, specifically those of translation, reprinting, re-use of iIIustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks
© 1990 by Springer-Verlag Wien Origina11y published by Springer-Verlag Wien- New York in 1990 Softcover reprint of the hardcover 1st edition 1990 Typesetting: Macmillan India Ltd., Bangalore Library of Congress Cataloging-in-Publicat ion Data. Madsen, 1. B. (Jiim Bo), 1951- . The effects of anaesthetics upon cerebral circulation and metabolism/J.B. Madsen, G.E. Cold. p. cm. Inc1udes bibliographical references. ISBN 978-3-7091-3682-9 ISBN 978-3-7091-3680-5 (eBook) DOI 10.1007/978-3-7091-3680-5 1. Anesthetics-Physiological effect. 2. Cerebral circulation. 3. Brain-Metabolism. 1. Cold, G.E. (Georg Emil), 1938 II. Title. [DNLM: 1. Anesthetics-pharmacology, 2. Blood Flow Velocity-drug effects. 3. Brain-blood supply. 4. Brain-metabolism. 5. Cerebrovascular Circulation-drug effects. WL 302 M183e] RD85.5.M34 1990. 615'. 781-dc20. 90-10097
ISBN 978-3-7091-3682-9
Preface
The science of neuroanesthesia is fascinating and the amounts of experimental and clinical studies are overwhelming. Very early in our carreer as neuroanesthesiologists our memory concerning this field was challenged. Consequently, we initiated this review which also summarizes our clinical studies of the effects of anesthetics upon cerebral blood flow and metabolism. The clinical studies were carried out at the Department of Anesthesiology, Hvidovre Hospital, Copenhagen, Denmark and the Department of Neuroanesthesia, Arhus University Hospital, Denmark. Accordingly, we want to thank the chiefs of these departments, Professor Henning Ruben and Erland Hansen, M.D., Hvidovre Hospital and Paul Agerskov, M.D., Arhus University Hospital. However, without the support by the chiefs of the respective neurosurgical departments it was impossible to accomplish the present clinical studies. We are grateful to Torkild Nerholm, M.D., Hvidovre Hospital and Professor Peter Rasmussen and Jens Buhl, M.D., Arhus University Hospital. We are deeply indebted to our collaborators in these clinical studies, both neurosurgeons and anesthesiologists, who have used their spare time and with enthusiasm have participated in the clinical studies. A special thank to the anesthesiologists Marianne Engberg, M
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