Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication
- PDF / 656,390 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 106 Downloads / 208 Views
ORIGINAL ARTICLE
Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication Jeroen Vinke 1 & Hans J. Kaper 1 & Arjan Vissink 2 & Prashant K. Sharma 1 Received: 23 January 2019 / Accepted: 4 April 2020 # The Author(s) 2020
Abstract Objectives The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF). Materials and methods Quartz crystal microbalance with dissipation was used to study the capability of saliva substitutes to interact with natural SCF and the ability to change the secondary SCF (S-SCF). A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and relief period expected from these substitutes under set circumstances. Results Saliva Orthana spray, Biotène spray and Gum Hydral gel had an immediate effect on a SCF, increasing its structural softness. BioXtra gel, Biotène gel, Gum Hydral gel and Glandosane spray changed the S-SCF by increasing salivary protein adsorption, while others showed no sign of interaction. With respect to relief, only 2 out of the 16 saliva substitutes tested (Saliva Orthana spray and Gum Hydral gel) performed better than water. Overall, relief period correlated positively to structural softness change, whereas a positive correlation was seen between relief and mass adsorption. Conclusions The majority of saliva substitutes did not adsorb on the SCF, thus did not enhance lubrication. Only saliva substitutes containing carrageenan, carboxymethylcellulose, pig gastric mucin, xanthan gum and carbomer performed better in enhancing oral lubrication. Clinical relevance This objective assessment will help clinicians and patients make better choice of saliva substitutes. This study provides a scientific basis for future improvement in saliva substitutes. Keywords Ageing . Quality of life . Salivary lubrication . Xerostomia . Saliva substitutes . Friction . Biotribology
Abbreviations ADM Aldiamed AT After treatment AQ Aequasyal BT Biotène BX BioXtra CMC Carboxymethyl cellulose COF Coefficient of friction DW Demineralized water * Prashant K. Sharma [email protected] 1
Department of Biomedical Engineering, University of Groningen and University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
2
Department of Oral Maxillofacial Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
DX E4 ES GDS GH HEC PEG QCM-D Rmedianr Rmedian,r Rmax Rmax,r RP RPr S-SCF SCF SCF AT SN
Dentaid Xeros A specific type of module for QCM-D Entertainer’s secret Glandosane GUM hydral Hydroxyethyl cellulose Polyethylene glycol Quartz crystal microbalance with disspation Relief calculated from median COF Rmedian after rehydration Relief calculated from maximum COF Rmax after rehydration Relief period RP after rehydration Seconda
Data Loading...
