DS21, a new noninvasive technology, is effective and safe for screening for prediabetes and diabetes in Chinese populati
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BioMedical Engineering OnLine Open Access
RESEARCH
DS21, a new noninvasive technology, is effective and safe for screening for prediabetes and diabetes in Chinese population Xiaopeng Zhu1,2†, Jing Tang3†, Huandong Lin1,2, Xinxia Chang1,2, Mingfeng Xia1,2, Liu Wang1,2, Hongmei Yan1,2*, Hua Bian1,2* and Xin Gao1,2 *Correspondence: yan.hongmei@zs‑hospital. sh.cn; [email protected]; [email protected] † Xiaopeng Zhu and Jing Tang have contributed equally to this work and should be considered co-first authors 1 Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Full list of author information is available at the end of the article
Abstract Background: Screening for prediabetes and asymptomatic diabetes is important for preventing development to an irreversible stage. The current diagnosis of prediabetes and diabetes is based on blood glucose or HbA1c (an invasive method). The aim of this study was to assess the efficacy and safety of DS21, a new noninvasive technology, for noninvasive screening for prediabetes and diabetes. Methods: A total of 939 subjects were divided into a normal control group (NC, n = 308), impaired glucose regulation group (IGR, n = 312), and diabetes (DM) group (n = 319). All subjects underwent the DS21 test, and mean hands–feet, hand, and feet conductance values were analyzed. The diagnostic accuracy of the conductance value was analyzed by receiver-operating characteristic (ROC) curve. Results: The conductance values for hands–feet, hands, and feet in the DM and IGR groups were significantly lower than those in the NC group (all P
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