Early changes in laboratory parameters are predictors of mortality and ICU admission in patients with COVID-19: a system
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ORIGINAL INVESTIGATION
Early changes in laboratory parameters are predictors of mortality and ICU admission in patients with COVID‑19: a systematic review and meta‑analysis Szabolcs Kiss1,3,4 · Noémi Gede1 · Péter Hegyi1,2 · Dávid Németh1 · Mária Földi1,3,4 · Fanni Dembrovszky1,2 · Bettina Nagy1 · Márk Félix Juhász1 · Klementina Ocskay1 · Noémi Zádori1,2 · Zsolt Molnár1,5 · Andrea Párniczky1,8 · Péter Jenő Hegyi1,2 · Zsolt Szakács1,2 · Gabriella Pár7 · Bálint Erőss1,2 · Hussain Alizadeh1,3,6 Received: 4 May 2020 / Accepted: 31 October 2020 © The Author(s) 2020
Abstract Despite the growing knowledge of the clinicopathological features of COVID-19, the correlation between early changes in the laboratory parameters and the clinical outcomes of patients is not entirely understood. In this study, we aimed to assess the prognostic value of early laboratory parameters in COVID-19. We conducted a systematic review and meta-analysis based on the available literature in five databases. The last search was on July 26, 2020, with key terms related to COVID-19. Eligible studies contained original data of at least ten infected patients and reported on baseline laboratory parameters of patients. We calculated weighted mean differences (WMDs) for continuous outcomes and odds ratios (ORs) with 95% confidence intervals. 93 and 78 studies were included in quantitative and qualitative syntheses, respectively. Higher baseline total white blood cell count (WBC), C-reactive protein (CRP), lactate-dehydrogenase (LDH), creatine kinase (CK), D-dimer and lower absolute lymphocyte count (ALC) ( WMDALC = − 0.35 × 109/L [CI − 0.43, − 0.27], p
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