Early-onset subclinical cardiovascular damage assessed by non-invasive methods in children with Juvenile Idiopathic Arth
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Rheumatology International https://doi.org/10.1007/s00296-020-04689-z
INTERNATIONAL
OBSERVATIONAL RESEARCH
Early‑onset subclinical cardiovascular damage assessed by non‑invasive methods in children with Juvenile Idiopathic Arthritis: analytical cross‑sectional study Karamalla Saddam Hussain1 · Reena Gulati1 · Santhosh Satheesh2 · Vir Singh Negi3 Received: 4 May 2020 / Accepted: 18 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery intima-media thickness (CIMT) between patients with JIA and healthy controls. Measurements of LVMi, CIMT and FMD and lipid profile were compared between 4 and 18 year old 81 patients with JIA and 78 age and sex matched healthy controls. Among 81, 20 had systemic onset, 19 enthesitis related arthritis, 9 polyarticular rheumatoid factor (RF) + ve, 19 polyarticular RF –ve, 11 oligo-articular, and 3 un-differentiated JIA. FMD was significantly lower (p
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