Effect of Chlamydia trachomatis on adverse pregnancy outcomes: a meta-analysis
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REVIEW
Effect of Chlamydia trachomatis on adverse pregnancy outcomes: a meta‑analysis Weihua He1 · Yue Jin1 · Haibin Zhu1 · Yan Zheng1 · Jianhua Qian1 Received: 13 January 2020 / Accepted: 18 June 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To analyze the effect of Chlamydia trachomatis (C. trachomatis) on adverse pregnancy outcomes based on the currently available evidence. Methods Multiple databases were comprehensively searched from the available date of inception through December 9, 2019. The effect of C. trachomatis on adverse pregnancy outcomes was assessed using pooled odds rations (ORs) and 95% confidence intervals (CIs). Egger’s test was used for publication bias. Results Fifty studies involving 502,141 participants were identified. C. trachomatis infection was found to be associated with preterm birth in antibody detection [OR (95% CI): 1.571 (1.112–2.220), P = 0.010] and high-quality assessment [OR (95% CI): 1.734 (1.295–2.321), P
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