Effect of Corticosteroid Therapy on the Duration of SARS-CoV-2 Clearance in Patients with Mild COVID-19: A Retrospective
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ORIGINAL RESEARCH
Effect of Corticosteroid Therapy on the Duration of SARS-CoV-2 Clearance in Patients with Mild COVID-19: A Retrospective Cohort Study Cheng Ding . Xuewen Feng . Yanfei Chen . Jing Yuan . Ping Yi . Yongtao Li . Qin Ni . Rongrong Zou . Xiaohe Li . Jifang Sheng . Lanjuan Li . Kaijin Xu
Received: July 21, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: In December, 2019, an outbreak of the coronavirus disease 2019 (COVID-19), which was caused by a novel coronavirus, started in Wuhan, China. So far, there is limited clinical evidence on the effect of corticosteroid therapy Cheng Ding and Xuewen Feng contributed equally to this work.
Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12860933. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40121020-00337-y) contains supplementary material, which is available to authorized users. C. Ding X. Feng Y. Chen P. Yi Y. Li Q. Ni J. Sheng L. Li (&) K. Xu (&) State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China e-mail: [email protected] K. Xu e-mail: [email protected] J. Yuan R. Zou X. Li Diagnosis and Treatment of Infectious Diseases Research Laboratory, Shenzhen Third People’s Hospital, Shenzhen, China
for this disease. This study aims to investigate the association between corticosteroid therapy and the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance among patients with mild COVID-19. Methods: Patients with mild COVID-19 were enrolled from two medical centers in China between January 13, 2020 and February 29, 2020. Baseline characteristics and durations of RNA clearance were compared between the corticosteroid and non-corticosteroid therapy groups. The independent effects of corticosteroid therapy on the duration of RNA clearance were estimated by generalized linear models. Results: Of 82 patients with a mild infection, 40 patients were male (48.8%), with a median age of 49 years (interquartile range, IQR 36–61). Among those patients, 36 patients (43.9%) received corticosteroid therapy. The adjusted multivariate models showed that the effects of corticosteroids were non-significant on the durations of onset to first RNA clearance [b 2.48, 95% CI (95% confidence interval) - 0.42 to 5.38, P = 0.0926] and to persistent RNA clearance (b 1.54, 95% CI - 1.41 to 4.48, P = 0.3016), and durations of therapy to first RNA clearance (b 2.16, 95% CI - 0.56 to 4.89, P = 0.1184) and to persistent RNA clearance (b 1.22, 95% CI - 1.52 to 3.95, P = 0.3787). Conclusions: Corticosteroid therapy in patients with mild COVID-19 was not associated with the duration of SARS-CoV-2 clearance, suggesting that the use of corticosteroids m
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