Effect of environmental toxicants on neuronal functions
- PDF / 794,193 Bytes
- 16 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 227 Views
REVIEW ARTICLE
Effect of environmental toxicants on neuronal functions Supriya Sharma 1 & Sharad Wakode 2 & Anjali Sharma 2 & Nisha Nair 2 & Mahaveer Dhobi 1 & Mushtaq Ahmad Wani 3 & Faheem Hyder Pottoo 4 Received: 21 June 2020 / Accepted: 20 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract In the last few years, neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) have attracted attention due to their high prevalence worldwide. Environmental factors may be one of the biggest reasons for these diseases related to neuronal dysfunctions. Most of neuronal disorders are strongly associated with pre- and postnatal exposure to environmental toxins released from industries. Some of the neurotoxic metals such as lead, aluminum, mercury, manganese, cadmium, and arsenic as well as some pesticides and metal-based nanoparticles have been involved in AD and PD due to their ability to produce senile/amyloid plaques and NFTs which are the main feature of these neuronal dysfunctions. Exposure to solvents is also majorly responsible for neurodegenerative disorders. The present review highlights the impact of omnipresent heavy metals with some other neurotoxins on human health and how they give rise to neuronal dysfunctions which in turn causes socio-economic consequences due to increasing pollution worldwide. Keywords Environmental factors . Alzheimer’s disease (AD) . Parkinson’s disease (PD) . Neurodegeneration . Neurotoxins . Socio-economic aspects
Introduction Rapid industrialization of rural sectors and excessive use of environmental toxicants such as heavy metals, hazardous solvents, and pesticides have alarmingly increased which has developed chemical burden on the society and exhibited serious risk factors of neuronal dysfunctions. Heavy metals such as lead, mercury, arsenic, aluminum, and manganese are Responsible editor: Lotfi Aleya * Faheem Hyder Pottoo [email protected] 1
Department of Pharmacognosy, Delhi Pharmaceutical Sciences and Research University, Sector-3, MB road, Pushp Vihar, New Delhi 110017, India
2
Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Sciences and Research University, Sector-3, MB road, Pushp Vihar, New Delhi 110017, India
3
Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Kolkata, 163, Maniktala Main road, Kolkata 700054, India
4
Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O.BOX 1982, Damman 31441, Saudi Arabia
known to be extensively noxious and have been associated with harmful neuronal effects like dementia, Alzheimer’s disease (AD), Parkinson’s disease (PD), schizophrenia, and amyotrophic lateral sclerosis (ALS) (Chen et al. 2016). Pesticides, another important classification of environmental pollutants, unfortunately cause toxic effects to non-target organisms, especially humans. Many studies have shown a strong association of increased risk of neurodegenerative diseases with pesticide exposure (B
Data Loading...
