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Exposure Toxicology in Caenorhabditis elegans

Exposure Toxicology in Caenorhabditis elegans

Dayong Wang

Exposure Toxicology in Caenorhabditis elegans

Dayong Wang Medical School Southeast University Nanjing, Jiangsu, China

ISBN 978-981-15-6128-3    ISBN 978-981-15-6129-0 (eBook) https://doi.org/10.1007/978-981-15-6129-0 © The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Preface

Toxicology and biology are reciprocal to a great degree. Toxicology and biology can and should have the potential to mirror each other. During the past 30 years, the nematode Caenorhabditis elegans has been widely and frequently used to assess the toxicity of different environmental toxicants or stresses. Due to the properties of model animal and the sensitivity to environmental exposures, C. elegans can be used to assess toxicity of various environmental toxicants or stresses even at environmentally relevant doses. Meanwhile, C. elegans has the potential to provide a powerful assay system for the study of both molecular toxicology and target organ toxicology at the whole animal level. We have introduced the knowledge system of molecular toxicology in “Molecular Toxicology in Caenorhabditis elegans” and the knowledge system of target organ toxicology in “Target Organ Toxicology in Caenorhabditis elegans.” Both the toxicity assessment and the toxicological study need the establishment of an exposure system in nematodes. The established exposure system in nematodes should at least satisfy these three aspects. Firstly, it should be useful to perfo