Effect of exercise intensity and blood glucose level on glucose requirements to maintain stable glycaemia during exercis
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ORAL PRESENTATION
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Effect of exercise intensity and blood glucose level on glucose requirements to maintain stable glycaemia during exercise in individuals with type 1 diabetes Shetty Vinutha1,2*, Fournier Paul3, Davey Raymond2,4, Retterath Adam4, Roby Heather4, Paramalingam Nirubasini1,4, Cooper Matthew4, Davis Elizabeth1,2,4, Jones Timothy1,2,4 From 8th APPES Biennial Scientific Meeting Darwin, Australia. 29 October – 1 November 2014 Current recommendations for carbohydrate supplementation to prevent exercise-induced hypoglycaemia in individuals with type 1 diabetes (T1D) do not take into account exercise intensity or blood glucose levels during exercise. The aim of these studies was to investigate the effects of (a) exercise intensity and (b) blood glucose levels, on carbohydrate requirements to maintain stable glycaemia during exercise in individuals with T1D at basal insulin levels and to determine the glucoregulatory mechanisms underlying these effects. Nine young adults with T1D underwent euglycaemic clamps, whereby stable blood glucose levels between 4.5 to 6mmol/L were maintained during the study at basal insulin levels. Participants performed up to 40 minutes of exercise at four different exercise intensities (35%, 50%, 65% and 80% VO2peak) on four separate days following a randomised counterbalanced design. In a subsequent experiment, eight participants underwent either a euglycaemic or hyperglycaemic (9.5 – 10.5mmol/L) clamp at basal insulin levels, during which they performed 40 minutes of exercise at 50% VO2peak, on two separate days. In both studies, glucose infusion rates (GIR) to maintain stable glycaemia were measured during exercise, constant deuterated glucose was infused to determine glucose kinetics and blood samples were collected for the analysis of glucoregulatory hormones. The average GIR to maintain euglycaemia during exercise was 2.0±0.9, 4.0±1.5, and 4.1±1.7g/h (mean±SEM) at
35%, 50% and 65% VO 2peak , respectively. These GIRs were all significantly greater than that at 80% VO 2peak where no glucose was required (p
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