Effect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomiz
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ORIGINAL CONTRIBUTION
Effect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomized double‑blind, placebo‑controlled trial Mengyue Li1,7 · Wen Li1,7 · Yiming Gao1,2 · Yongjie Chen3,7 · Dong Bai1,4 · Jinxi Weng5 · Yue Du6,7 · Fei Ma3,7 · Xinyan Wang1,7 · Huan Liu1,7 · Guowei Huang1,7 Received: 29 October 2019 / Accepted: 19 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose This study aimed to assess the effects of folic acid (FA) combined with a docosahexaenoic acid (DHA) intervention on the cognitive function and inflammatory cytokines in elderly subjects with mild cognitive impairment (MCI). Methods This randomized, double-blind, placebo-controlled trial recruited 240 individuals with MCI in Tianjin, China, and randomly allocated into 4 groups: FA + DHA (FA 800 μg/d + DHA 800 mg/d), FA (FA 800 μg/d), DHA (DHA 800 mg/d), and placebo. Cognitive function, serum folate and homocysteine (Hcy), plasma DHA and inflammatory cytokines levels were measured at baseline and 6 months. Results Daily oral FA, DHA and their combined use for 6 months significantly improved the full-scale intelligence quotient (FSIQ) and some subtests of Wechsler Adult Intelligence Scale compared to the placebo. The increases of FSIQ, arithmetic, picture completion scores in the FA group and picture completion, block design scores in the DHA group were significantly less than that in the FA combined DHA group (P
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