Effect of TRP-Stimulating Compounds to Reduce Swallowing Response Time in the Elderly: A Systematic Review
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ORIGINAL ARTICLE
Effect of TRP‑Stimulating Compounds to Reduce Swallowing Response Time in the Elderly: A Systematic Review Pajeemas Kittipanya‑ngam1 · Paitoon Benjapornlert2 · Siwanon Rattanakanokchai3 · Pattra Wattanapan1 Received: 3 October 2019 / Accepted: 24 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract There is still controversy on evidence supporting compounds that stimulate the transient receptor potential cation channel (TRP) receptor, which can reduce the latency of swallowing reflex. This systematic review aims to evaluate the effectiveness of TRP-stimulating compounds to reduce swallowing reflex time in the elderly. We searched the following databases: PubMed, EMBASE, OVID, Central, Scopus, ISI, CINALH, LILACS, CRD database, and Open grey until June 1st, 2019. We included randomized controlled trials (RCTs) which compared swallowing time between TRP-stimulating compounds and placebo or no treatment in population aged more than 60 years old. We assessed bias using the Cochrane risk of bias tool. Three authors independently screened and selected studies. Quality assessment and data extraction were performed by two authors independently. Of 363 reviews, we included four RCTs. Two RCTs used black pepper, one RCT used capsaicinoids, and the other one used capsaicin ointment to stimulate the TRPV1 receptor. All of the studies were assessed at unclear bias except the study, which used capsaicin ointment with assessed as low risk of bias. Meta-analysis could not be done in this study due to the different baseline characteristics and definition of swallowing reflex time. This review demonstrates the potential effect of TRPV1-stimulating compounds to reduce swallowing response time in the elderly were remains unclear. Most studies had an unclear bias. Further larger and well-designed RCTs are needed to draw robust conclusions. Keywords TRP-stimulating compounds · Swallowing response · Elderly
Background In these days, people worldwide live longer. World Health Organization reported that the world population over 60 years old would rise from 12% in 2015 to 22% in 2050. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00455-020-10175-2) contains supplementary material, which is available to authorized users. * Paitoon Benjapornlert [email protected] 1
Department of Rehabilitation Medicine, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Rd., Nai Mueang, Mueang Khon Kaen District, Khon Kaen 40000, Thailand
2
Department of Rehabilitation Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd., Ratchathewi, Bangkok 10400, Thailand
3
Faculty of Public Health, Khon Kaen University, 123 Mittraphap Rd., Nai Mueang, Mueang Khon Kaen District, Khon Kaen 40000, Thailand
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