Effects of Comorbidities on the Elderly Patients with COVID-19: Clinical Characteristics of Elderly Patients Infected wi
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EFFECTS OF COMORBIDITIES ON THE ELDERLY PATIENTS WITH COVID-19: CLINICAL CHARACTERISTICS OF ELDERLY PATIENTS INFECTED WITH COVID-19 FROM SICHUAN, CHINA S.-P. DAI1, X. ZHAO2, J.-H. WU1 1. National Center for Geriatrics Clinical Medicine Research, Department of Geriatrics and Gerontology, West China Hospital, Sichuan University, Chengdu, China; 2. The Public Health Clinical Center Of Chengdu, ICU-2, Chengdu, China. Corresponding author: Jin-hui Wu, National Center for Geriatrics Clinical Medicine Research, Department of Geriatrics and Gerontology, West China Hospital, Sichuan University, Chengdu, 610041, China, [email protected]
Abstract: Objectives: The co-occurrence of chronic diseases in the elderly is a common problem. However, the relationship between comorbidities and the prognosis of elderly patients with COVID-19 was not clear. This study was supposed to describe the clinical characteristics of elderly patients with COVID-19 infection from Sichuan province and the effects of comorbidity. Design: A retrospective study. Settings and participants: COVID-19 patients from Public Health Clinical Center of Chengdu between December 16, 2019 and February 26, 2020 were included in this study. Patients were divided into elderly group (≥60 years old) and non-elderly group (< 60 years old). Results: Elderly patients with COVID-19 indicated relatively higher proportion of comorbidities, and the most common were atherosclerotic cardiovascular disease (56.5%), hypertension (43.5%) and chronic pulmonary disease (21.7%). The proportion of severe cases was higher in elderly group than that in non-elderly group (73.9% and 42.2%, respectively, P=0.012). During hospitalization, elderly patients indicated relatively higher proportion of complications, such as shock (21.7%), respiratory failure (21.7%). The proportion of patients with a decreased number of CD8+ lymphocytes (82.6%) and B lymphocytes (77.8%) in elderly patients was significantly higher than that in non-elderly group (48.9% and 44.8%, respectively). All 3 deaths were elderly patients with comorbidities and the cell counts of T lymphocyte subsets, B and NK cells of them were significantly decreased at admission. Conclusions: Elderly patients with COVID-19 had a high proportion of severe cases and comorbidities, more likely to show low immune function, and indicate higher proportion of complications. Key words: COVID-19, comorbidities, elderly, clinical characteristics, Sichuan Province.
Introduction
COVID-19 infection and the effects of comorbidity by comparing with non-elderly patients.
In December 2019, pneumonia of unknown cause broke out in Wuhan, China (1). The pathogen has been identified and was named as «COVID-19» in February 11, 2020 (2). Older populations are more susceptible to variety of diseases compared to younger, including COVID-19 infection (3, 4). Although the entire population is susceptible to the COVID-19, older patients had higher morbidity and case-fatality rate (5). The mortality rate (4.5%) of the people over 60 years old was much higher th
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