Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodi
- PDF / 1,068,781 Bytes
- 17 Pages / 595.276 x 790.866 pts Page_size
- 62 Downloads / 186 Views
ORIGINAL RESEARCH
Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis: A Prospective Observational Exploratory Study Tomomi Ishikawa-Tanaka . Michihiro Hosojima
. Hideyuki Kabasawa .
Ryohei Kaseda . Ryota Yasukawa . Yusuke Yata . Shoji Kuwahara . Emiko Kono . Takuma Takata . Noriaki Iino . Takahiro Tanaka . Nobutaka Kitamura . Yoshiki Suzuki . Akihiko Saito . Ichiei Narita Received: July 20, 2020 / Accepted: September 11, 2020 The Author(s) 2020
ABSTRACT Introduction: The precise blood glucose (BG) profile of hemodialysis patients is unclear, as is the effectiveness of dipeptidyl peptidase-4 (DPP4) inhibitors in hemodialysis patients with type 2 diabetes. Here, we used continuous glucose monitoring (CGM) to evaluate BG variability in these patients and to assess the efficacy of DPP-4
Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/m9.figshare. 12937694. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13300020-00928-5) contains supplementary material, which is available to authorized users. T. Ishikawa-Tanaka R. Kaseda R. Yasukawa Y. Yata I. Narita Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan T. Ishikawa-Tanaka Department of Internal Medicine, Itoigawa General Hospital, Niigata, Japan M. Hosojima (&) H. Kabasawa Department of Clinical Nutrition Science, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan e-mail: [email protected]
inhibitors, particularly during hemodialysis sessions and at nighttime (UMIN000012638). Methods: We examined BG profiles using CGM in 31 maintenance hemodialysis patients with type 2 diabetes. Differences between patients with and without DPP-4 inhibitors (n = 15 and 16, respectively) were analyzed using a linear mixed-effects model to assess changes in glucose levels in 5-min intervals. Results: The model revealed that DPP-4 inhibitor use was significantly associated with suppression of a rapid drop in glucose levels, both with and without adjustment for BG levels at the start of hemodialysis. Moreover, the model revealed that the two groups differed significantly in the pattern of changes in BG levels from 0:00 to 6:55 am. DPP-4 inhibitors S. Kuwahara A. Saito Department of Applied Molecular Medicine, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan E. Kono T. Takata Department of Nephrology, Nagaoka Chuo General Hospital, Niigata, Japan N. Iino Department of Nephrology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan
Diabetes Ther
suppressed the tendency for subsequent nocturnal hypoglycemia. Conclusions: This prospective observational exploratory study showed that DPP-4 inhibitors could suppress BG variability
Data Loading...
