Effects of emotional and physiological stress on plaque instability in apolipoprotein E knockout mice
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ORIGINAL PAPER
Effects of emotional and physiological stress on plaque instability in apolipoprotein E knockout mice Tao Zhang & Yongzhi Zhai & Yundai Chen & Zhenhong Zhou & Junjie Yang & Hongbin Liu
Received: 22 October 2010 / Accepted: 23 February 2011 / Published online: 22 April 2011 # University of Navarra 2011
Abstract In the present study, we sought to investigate the effects of emotional and physiological stress on plaque instability in atherosclerosis. We used different stress-treated apolipoprotein E (ApoE)-deficient mice, which have been shown to spontaneously develop atherosclerosis with features similar to those seen in humans, as an animal model. Morphology study showed that emotional stress (ES) obviously promoted the development of atherosclerotic plaques and plaque instability evidenced by significantly increasing plaque size, plaque-to-surface ratio and plaque calcification, and enhancing the frequency of large necrotic core and medial erosion compared with control ApoE−/− mice (P0.05). However, the combination of ES and PS treatment (CS) initiated much stronger plaque instability compared with ES treatment alone Tao Zhang and Yongzhi Zhai equally contributed to this work and share the first authorship T. Zhang : Y. Chen : J. Yang : H. Liu (*) Department of Cardiology, PLA General Hospital, Beijing 100853, China e-mail: [email protected] Y. Zhai Department of Emergency, PLA General Hospital, Beijing 100853, China Z. Zhou Department of Pathology, PLA General Hospital, Beijing 100853, China
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