Effects of Nano-Copper Poisoning on Immune and Antioxidant Function in the Wumeng Semi-Fine Wool Sheep
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Effects of Nano-Copper Poisoning on Immune and Antioxidant Function in the Wumeng Semi-Fine Wool Sheep ChunJie Song 1 & Shangquan Gan 2 & Xiaoyun Shen 1,3 Received: 2 February 2020 / Accepted: 18 February 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The Wumeng semi-fine wool sheep is vital to the production system of the Wumeng mountainous area in Southwest China. To study the effect of nano-copper poisoning in the Wumeng semi-fine wool sheep, nano-copper poisoning model was established in sheep. We determined blood physiological and biochemical parameters, immune indexes, and antioxidant indicators. The results showed that Hb, RBC, and PCV levels in blood from the nano-copper group were markedly lower (P < 0.01) than those in the control group. Serum LDH, AST, ALT, CPK, and Cp from the nano-copper group were significantly higher (P < 0.01) than those in control animals. Serum SOD, GSH-Px, CAT, and T-AOC from the nano-copper group were significantly lower (P < 0.01) than those in control sheep, and MDA content in serum from the nano-copper group were markedly higher (P < 0.01) than those in control sheep. The levels of IL-2, IL-6, IL-1β, IgA, IgM, and IgG from the nano-copper group were significantly lower (P < 0.01) than those in the control group. It was concluded that nano-copper poisoning could not only affect the immune function of Wumeng semi-fine wool sheep but also reduce the antioxidant capacity. Keywords Nano-copper . The Wumeng semi-fine wool sheep . Immune function . Antioxidant capacity . The Wumeng mountainous area
Introduction Nano-copper is a common artificial metal nano-material. It can not only be used as animal feed additive, anti-osteoporosis, and anti-aging nano-medicine and intrauterine device in biomedical field [1, 2] but also as lubricant additive, highefficiency catalyst, and surface coating of electronic products in industrial field, bringing technological revolution to the development of animal husbandry and industry [3–5]. In recent years, some scholars have preliminarily discussed the toxic mechanism of nano-copper. They think that nanocopper may play a role by reacting copper (Cu) ions and Cu particles in low-pH gastric juice. But, some scholars found
* Xiaoyun Shen [email protected] 1
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China
2
State Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Sciences, Shihezi, Xinjiang 832000, China
3
World Bank Poverty Alleviation Project Office in Guizhou, Southwest China, Guiyang 550004, China
that nano-copper can damage mitochondrial function and enhance ketone formation, fatty acid β oxidation, and glycolysis process [6–8]. Furthermore, it can damage the liver, kidney, spleen, and nervous system [9, 10] and bring potential negative effects on human health and the ecosystem [11]. The Wumeng semi-fine wool sheep, formerly Guizhou semi-fine wool sheep, is mainly distributed i
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