Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits
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BioMed Central
Open Access
Original basic research
Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits Olímpio Ribeiro França Neto, Dalton Bertolim Precoma, Alexandre Alessi, Camila Prim, Ruy Fernando Kuenzer Caetano da Silva, Lucia de Noronha and Liz Andréa Villela Baroncini* Address: Center of Health and Biological Sciences-Pontifical Catholic University of Paraná, Rua Imaculada Conceição, 1155, Prado Velho, CEP: 80215-901 Curitiba- Paraná –, Brazil Email: Olímpio Ribeiro França Neto - [email protected]; Dalton Bertolim Precoma - [email protected]; Alexandre Alessi - [email protected]; Camila Prim - [email protected]; Ruy Fernando Kuenzer Caetano da Silva - [email protected]; Lucia de Noronha - [email protected]; Liz Andréa Villela Baroncini* - [email protected] * Corresponding author
Published: 16 May 2008 Thrombosis Journal 2008, 6:4
doi:10.1186/1477-9560-6-4
Received: 8 November 2007 Accepted: 16 May 2008
This article is available from: http://www.thrombosisjournal.com/content/6/1/4 © 2008 Neto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: The objective was to evaluate the effects of rosiglitazone on iliac arteries of hypercholesterolemic rabbits undergoing balloon catheter injury in the contralateral iliac arteries. Methods: White male rabbits were fed a hypercholesterolemic diet for 6 weeks and divided into two groups as follows: rosiglitazone group, 14 rabbits treated with rosiglitazone (3 mg/Kg body weight/day) during 6 weeks; and control group, 18 rabbits without rosiglitazone treatment. All animals underwent balloon catheter injury of the right iliac artery on the fourteenth day of the experiment. Results: There was no significant difference in intima/media layer area ratio between the control group and the rosiglitazone group. Rosiglitazone did not reduce the probability of lesions types I, II, or III (72.73% vs. 92.31%; p = 0.30) and types IV or V (27.27% vs. 7.69%; p = 0.30). There were no differences in the extent of collagen type I and III deposition or in the percentage of animals with macrophages in the intima layer. The percentage of rabbits with smooth muscle cells in the intima layer was higher in rosiglitazone group (p = 0.011). Conclusion: These findings demonstrate that rosiglitazone given for 6 weeks did not prevent atherogenesis at a vessel distant from the injury site.
Background Balloon angioplasty is a common intervention for treatment of blood vessel stenosis, particularly in coronary vasculature. However, the balloon directly inflicts significant trauma to the vascular endothelium, which is evidenced by an immediate loss of endothelial-dependent relaxation, and is associated with a concomitant induc-
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