Rosiglitazone
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Proptosis in an elderly patient: case report A 67-year-old man developed proptosis during treatment with rosiglitazone for type 2 diabetes mellitus. The man, who also had hypertension, presented with persistent and progressive bilateral oedema of his upper and lower eyelids 2.5 years after starting treatment with rosiglitazone [dosage not stated]. He reported that he had had concerns about the progressive lid oedema since starting the agent. His other medications comprised amlodipine/benazepril, metformin and glipizide. An examination revealed proptosis with Hertel measurements of 23mm on the right and 25mm on the left, with marked oedema in the periocular region bilaterally. Resistance to retropulsion of both eyes was also evident, and was more pronounced on the left. Mild lid lag on down-gaze and subtle retraction of the left upper eyelid was also evident. He had a mild deficit in supraduction of the left eye and abduction of both eyes. Orbital CT scans revealed bilateral proptosis and an increase in the fat volume within the orbit. It was recommended that rosiglitazone be discontinued and the man was scheduled for orbital decompression. [Patient outcome not stated.] Yang CCL, et al. Proptosis secondary to rosiglitazone treatment. International 801158052 Journal of Diabetes and Metabolism 16: 89-90, No. 2, 2008 - USA
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Reactions 9 Jan 2010 No. 1283
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