Effects of the Association of Periodontitis and Type 1 Diabetes Mellitus Induced on Periodontal Tissues and the Duodenal
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ORIGINAL ARTICLE
Effects of the Association of Periodontitis and Type 1 Diabetes Mellitus Induced on Periodontal Tissues and the Duodenal Mucosa of Wistar Rats Iohana Ferreira Choptian Fiorese,1 Jossinelma Camargo Gomes,1 Bianca Caroline Custódio dos Santos,1 Franciane Wachter,2 Ediana Amanda Piana,2 Rose Meire Costa Brancalhão,2 Sabrina Grassioli,3 Carlos Augusto Nassar,4 and Patrícia Oehlmeyer Nassar 4,5 Received April 23, 2020; accepted October 15, 2020
Abstract— Forty Wistar rats were used: (1) control group (CG); (2) group of periodontal disease
(PD); (3) type 1 diabetes mellitus group (T1DM); (4) type 1 diabetes mellitus + periodontal disease group (T1DM + PD). In groups T1DM and T1DM + PD, T1DM induction was performed with the administration of streptozotocin (STZ) 80 mg/kg intraperitoneal body weight. The PD and T1DM + PD groups were submitted to PD induction with ligation. After the experimental phase and euthanasia, histological, radiographic, and morphological analyses were performed. For data analysis, was used the one-way ANOVA and post-test Tukey. The T1DM + PD group had a significantly higher level of fasting blood glucose compared to the other groups. In radiographic and histomorphometric analyses, the T1DM + PD group showed greater alveolar bone loss compared to the control group. The T1DM + PD group showed greater osteoclastic activity compared to the control, T1DM, and PD groups and exhibited an intense inflammatory infiltrate, most of which were PMN, being that the amount of this group of cells (PMN) was significantly greater than the PD group. The heights of the intestinal villi were statistically higher in the PD, T1DM, T1DM + PD groups, compared to the control. Regarding the height of the crypt, only the T1DM and T1DM + PD groups were significantly higher compared to the other groups. Association of diabetes and periodontal inflammation increased the deleterious effects on bone tissue and adverse effect on the permeability of the duodenal mucosa. KEY WORDS: periodontitis; diabetes mellitus; duodenum; inflammation.
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State University of Western Paraná, Cascavel, Paraná, Brazil Laboratory of Structural and Functional Biology, State University of Western Paraná, Cascavel, Paraná, Brazil 3 Department of Periodontology, School of Dentistry, State University of Western Paraná, Cascavel, Paraná, Brazil 4 Department of Periodontology, School of Dentistry, State University of Western Paraná, Torres Avenue, Number 200, House 249, FAG, Cascavel, Paraná Postal Code 85806-095, Brazil 5 To whom correspondence should be addressed at Department of Periodontology, School of Dentistry, State University of Western Paraná, Torres Avenue, Number 200, House 249, FAG, Cascavel, Paraná Postal Code 85806-095, Brazil. E-mail: [email protected]
INTRODUCTION
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Periodontal disease (PD) is considered an essential public health problem due to its high prevalence in humanity; its severe form affects about 740 million people worldwide [1]. This disease is a complex infectious inflammatory condition with multifactori
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