Effects of Weak Static Magnetic Field and Oligopeptides on Cell Proliferation and Cognitive Functions in Different Anima
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RACTION OF WEAK ELECTROMAGNETIC FIELDS (WEF) WITH LIVING CELLS AND ORGANISMS
Effects of Weak Static Magnetic Field and Oligopeptides on Cell Proliferation and Cognitive Functions in Different Animal Species E. S. Zalomaevaa,b,*, P. N. Ivanovaa,b, N. I. Chalisovaa, S. V. Surmaa, E. V. Tokmachevaa, E. V. Savvateeva-Popovaa, B. F. Shchegoleva, and E. A. Nikitinaa,b a Pavlov
Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034 Russia b Herzen State Pedagogical University, St. Petersburg, 191186 Russia *e-mail: [email protected]
Received December 12, 2019; revised February 16, 2020; accepted February 17, 2020
Abstract—The effects of exposure to two different stress factors—a weak static magnetic field (WSMF) with a magnetic induction of 200 μT and oligopeptide epigenetic regulators—were studied. The results of explant exposure to tissue-specific oligopeptides and to WSMF were comparable. Experiments on cognitive behavior suggested that oligopeptides Ala–Glu–Asp–Pro and Lys–Glu–Asp–Ala had a beneficial effect on mediumterm memory formation. It is noted that external WSMFs efficiently affect biological objects due to their high penetrating capacity in biological media. DOI: 10.1134/S1063784220100254
INTRODUCTION A central problem of modern neurophysiology and medicine is represented by the investigation of mechanisms that underlie socially significant diseases, in particular, neurodegenerative and cardiovascular diseases, neoplasms, and infections. These conditions develop as a result of complex interactions between adverse environmental factors and individual genetic features predisposing to the disease, and a significant role belongs to exposure to various stress factors. Static magnetic fields with low induction levels of up to 300 μT are among the less studied stress factors that can have an effect on living organisms, including human beings. Initially, it was assumed that fields with magnetic induction of up to 30 mT were safe for human beings. However, a substantial body of data accumulated in recent years indicates that such fields represent a potential hazard. In 2002, the World Health Organization admitted that long-term exposure to magnetic fields with an induction of 300 nT and above might have a carcinogenic effect in human beings [1]. In addition, weak static magnetic fields (WSMF) of up to 300 μT can affect various organism’s functions, primarily the work of the nervous, cardiovascular, and reproductive systems. The changing static magnetic field of the Earth has been affecting the evolution of living organisms throughout the entire history of life. Observations of the recent decades show that the poles of the geomagnetic field have been constantly migrating; moreover,
the rate of their migration increased from 15 km/year in 2000 to 55 km/year in 2019, but this fact was not taken this into account in our study. The geomagnetic field is not uniform; there exist regions with elevated background geomagnetism, such as the Kursk Magnetic Anomaly with a magnetic induction level of ~200 μT a
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