Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the
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RESEARCH ARTICLE
Open Access
Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: a Norwegian 2-year prospective multicenter pilot study Paula Frid1,2,3* , Thomas A. Augdal3,4, Tore A. Larheim5, Josefine Halbig2,3, Veronika Rypdal3,6, Nils Thomas Songstad6, Annika Rosén7,8, Karin B. Tylleskär9, Johanna Rykke Berstad10, Berit Flatø11,12, Peter Stoustrup13, Karen Rosendahl3,4, Eva Kirkhus14 and Ellen Nordal3,6
Abstract Background: Intraarticular corticosteroids (IACs) have been used to treat temporomandibular joint (TMJ) arthritis. However, prospective clinical studies with magnetic resonance imaging (MRI) scoring are lacking. The aim of this study was to examine efficacy and safety of a single IAC in the TMJ in adolescents with juvenile idiopathic arthritis (JIA) in a clinical setting. Methods: In this Norwegian prospective multicenter pilot study 15 patients with JIA (mostly persistent oligoarthritis or RF negative polyarthritis categories) and a clinically and MRI-verified diagnosis of TMJ arthritis were treated with IACs and followed for 2 years. Demographics, systemic medication, general disease activity and outcome measures were recorded including a pain-index score and maximal incisal opening (MIO). Inflammation and bone damage scores were assessed, using two recently published MRI scoring systems with masked radiological evaluation. (Continued on next page)
* Correspondence: [email protected] 1 Department of Otorhinolaryngology, Division of Oral and Maxillofacial Surgery, University Hospital North Norway, Tromsø, Norway 2 Public Dental Service Competence Centre of North Norway, Tromsø, Norway Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Frid et al. Pediatric Rheumatology
(2020) 18:75
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Results: Among the 15 patients, 13 received a single IAC (5 bilateral), and 2 repeated IACs on
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