Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis
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hinese Journal of Integrative Medicine
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Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Acupuncture Research
Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis: A Randomized Controlled Trial LI You-jin1, ZONG Ming2, DING Li-feng3, RUI Xiao-qing1, MA Bei-yin4, and QIN Li-ping5 Objective:: To evaluate the efficacy of Chinese medicine acupoint application (CMAA) combined with ABSTRACT Objective Methods:: In this prospective, parallel, randomized, Western medicine for perennial allergic rhinitis (PAR) in children. Methods placebo-controlled and single-blind trial from August to September, 2017, 180 children with PAR were randomly assigned to an integrative group (CMAA and Montelukast), CMAA group (CMAA and placebo tablet), or Montelukast group (placebo CMAA and Montelukast). Participants were applied with CMAA for 6 sessions over 2 weeks, and/or Montelukast Chewable Tablet orally once daily for 12 weeks. The changes in severity of symptoms were measured by Visual Analog Scale (VAS) and rhinitis control assessment test (RCAT) at 0, 2, 4 and 12 weeks of treatment. Blood samples were collected for serum interleukin-4, interferon gamma γ and T helper type 1 (Th1)/Th2 flow cytometric Results:: Eight cases dropped out from the trial, 3 in the integrative analysis at the time points of 0, 4 and 12 weeks. Results group, 2 in the CMAA group and 3 in the Montelukast group. The VAS scores decreased significantly while the RCAT scores increased significantly in all three groups at 4 and 12 weeks compared with baseline (P
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