Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial
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RESEARCH ARTICLE
Open Access
Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial Li Jia, Meng Xie, Jing Zhang, Jingyu Guo, Tong Tong and Yuying Xing*
Abstract Background: Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination. This study was to evaluate the effects of different doses of the dexmedetomidine-remifentanil combination in colonoscopy. Methods: This was a prospective trial carried out at the Fourth Hospital of Hebei Medical University between 02/ 2018 and 10/2018. The patients were randomized: group I (dexmedetomidine 0.2 μg·kg− 1), group II (dexmedetomidine 0.3 μg·kg− 1), and group III (dexmedetomidine 0.4 μg·kg− 1), all combined with remifentanil. The primary outcomes were the patient’s body movements during the procedure and adverse events. Results: Compared with at admission (T0), the SBP, HR, and RR at immediately after giving DEX (T1), at the beginning of the examination (T2), 5 min after the beginning of the examination (T3), 10 min after the beginning of the examination (T4), and at the end of the examination (T5) in the three groups were all reduced (all P < 0.05), but all were within the clinically normal range. SpO2 remained > 98% in all patients during the examination. Compared with T0, the BIS values of the three groups were decreased at T1 and T2 (all P < 0.05). There were no significant differences in BIS among the three groups (all P > 0.05). The minimum BIS value in group III was lower than in groups I and II (P < 0.05). The degree of satisfaction with the anesthesia effect was higher in groups II and III that in group I (P < 0.05). No hypotension occurred, seven patients had bradycardia, and four patients had nausea/ vomiting. Conclusions: Dexmedetomidine 0.3 μg·kg− 1 combined with remifentanil was effective for colonoscopy and had few adverse reactions. Chinese Clinical Trial Registry: ChiCTR2000029105, Registered 13 January 2020 - Retrospectively registered. Keywords: Colonoscopy, Dexmedetomidine, Piperidines, Analgesia, Conscious sedation
Background Colonoscopy can be performed for the screening of cancer, adenomas, and polyps, for the assessment of known or possible bleeding, and for the evaluation of possible * Correspondence: [email protected] Department of Anesthesiology, Fourth Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang 050000, Hebei, China
causes of abdominal pain, gastrointestinal symptoms, and/or changes in bowel habits [1, 2]. The National Colorectal Cancer Roundtable aims to reach 80% screening prevalence in the eligible American population [3, 4], representing 5.1 million colonoscopies each year [5]. Beyond the discomfort and inconveniences associated with bowel preparation [6], colonoscopy is
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation,
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