Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study
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LETTER
Efficacy of early prone position for COVID‑19 patients with severe hypoxia: a single‑center prospective cohort study Xuefeng Zang1, Qian Wang2, Hua Zhou3*, Sanhong Liu4,5* and Xinying Xue6,7* on behalf of COVID-19 Early Prone Position Study Group © 2020 The Author(s)
Dear Editor, With the global epidemic of COVID-19, as of July 8, 2020, 12,025,348 people have been infected with 4.56% mortality [1]. Many COVID-19 patients died due to severe hypoxia [2, 3]. It is particularly important to find a simple and effective way for COVID-19 patients’ treatment. Recent studies reported that prone position was used to treat non-intubated COVID-19 patients and hypoxemic acute respiratory failure [4, 5]. However, the number of patients was small, the follow-up was short, clinical outcomes were not assessed in their study. In this study, we aimed to explore whether the early prone position can effectively improve severe hypoxia, CT imaging performance and survival prognosis of COVID-19 patients with severe hypoxia. A total of 60 COVID-19 patients with severe hypoxia were enrolled from February 1, 2020 to April 30, 2020 (Fig. S1, Tables S1 and S2) (Chinese Clinical Trial Registry: ChiCTR2000033053). And 23 patients were taken early prone position and 37 patients were not. In prone *Correspondence: [email protected]; [email protected]; [email protected] 3 Department of Critical Care Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China 4 Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China 6 Department of Respiratory and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Full author information is available at the end of the article Xuefeng Zang and Qian Wang contributed equally to this work. Hua Zhou, Sanhong Liu and Xinying Xue contributed equally to this work. The members of the COVID-19 Early Prone Position Study Group are listed in the Acknowledgements.
position group, the pulse oxygen saturation (SpO2) increased from 91.09 ± 1.54% to 95.30 ± 1.72% (P
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