Efficacy of platelet-rich plasma injections in patients with adhesive capsulitis of the shoulder
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ORIGINAL PAPER
Efficacy of platelet-rich plasma injections in patients with adhesive capsulitis of the shoulder Burcu Ünlü 1 & Funda Atamaz Çalış 1 & Hale Karapolat 1 & Asude Üzdü 1 & Göksel Tanıgör 1
&
Yeşim Kirazlı 1
Received: 12 October 2019 / Accepted: 27 February 2020 # SICOT aisbl 2020
Abstract Purpose The goal of this study is to investigate whether platelet-rich plasma (PRP) injections are effective in the management of adhesive capsulitis of the shoulder (AC). A triple-blind, randomized controlled trial was designed and conducted in a medical school hospital. Methods 32 adult patients with adhesive capsulitis (21 female, 11 male with a mean age of 57, ranging from 23 to 70) were included in this study. Patients had to have shoulder pain and restrictions in movements (at least 25% when compared to the other side, and at least in two directions) for three months minimum and nine months maximum. Patients were randomized to two groups, and one group took PRP injections for three times every two weeks, while the other group took saline injections in same frequency and volume. A standardized exercise program was also applied to all patients. Patients were evaluated with Shoulder Pain and Disability Index (SPADI), Visual Analogue Scales for pain and disability, ranges of movements, and use of analgesics in before, after, and third month after the initiation of the therapy. Results Baseline comparisons between groups showed no differences. SPADI and ranges of motion in all directions showed significant improvements with therapy, and the group which took PRP injections showed better improvements when compared to the control group (p < 0.05). Visual Analogue Scale was found to be better for the PRP group after therapy and third month, and not for the control group (0.4 ± 1.06 and 0.17 ± 0.72 vs. 2.5 ± 2.6 and 2 ± 2.2, respectively, p < 0.05). Use of analgesics was not found to be significant for both groups (p > 0.05). Conclusion PRP injections were found to be effective in both pain and disability, and showed improvements in a restricted shoulder due to adhesive capsulitis. These findings might point out PRP as a therapeutic option in the management of adhesive capsulitis. Keywords Frozen shoulder . Adhesive capsulitis . Platelet-rich plasma . PRP . SPADI . Range of motion Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00264-020-04518-9) contains supplementary material, which is available to authorized users. * Burcu Ünlü brc—[email protected] * Göksel Tanıgör [email protected] Funda Atamaz Çalış [email protected] Hale Karapolat [email protected] Asude Üzdü [email protected] Yeşim Kirazlı [email protected] 1
Department of Physical Medicine and Rehabilitation, Ege University Medical School, Bornova, 35100 İzmir, Turkey
Introduction Adhesive capsulitis of the shoulder (AC) is a disease characterized with pain and restriction in ranges of movement in shoulder. While it is reported to be common, prevalence being from 2% to 5.3%, its etiology
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