Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats
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ORIGINAL ARTICLE
Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats Bingquan Ma,1,2 Peng Li ,1,2 Hengyuan An,1 and Zhiming Song1
Nonalcoholic fatty liver disease (NAFLD) has become a major health concern worldwide. The aim of this study was to investigate the effect and mechanism of electroacupuncture (EA) on nonalcoholic fatty liver disease (NAFLD) in rats induced by high-fat diet (HFD). A model of nonalcoholic fatty liver in rats induced by high fat was established. Rats in the control group were fed standard diet. The rats in model group and EA group were fed with HFD. From the fifth week, the rats in EA group were treated with EA (“FengLongXue,” “YinLingQuanXue,” “SanYinJiaoXue”) for 2 weeks respectively. EA could significantly reduce serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum triglyceride (TG), serum cholesterol (TC), and serum cytokines, and improve liver histopathological changes in rats. EA also could regulate the levels of Sirt1/NF-κB pathway in rat liver. EA relieved liver injury in NAFLD rats, and its mechanism may be related to the regulation of Sirt1/NF-κB pathway in rats. This is the first report that electroacupuncture alleviates liver inflammatory reaction of nonalcoholic fatty liver by enhancing Sirt1 expression and inhibiting NLRP3/NF-kB signal pathway.
Abstract—
KEY WORDS: electroacupuncture; nonalcoholic fatty liver disease (NAFLD); high-fat diet (HFD); Sirt1/NF-κB.
INTRODUCTION Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, is an obesityrelated disease [1], and is a systemic disease caused by interaction between specific genetic background and various environmental/metabolic factors [2]. NAFLD mainly induces fatty degeneration of liver due to accumulation of triglyceride level, biochemical characteristics of NAFLD
1
Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China 2 To whom correspondence should be addressed at Department of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. E-mails: [email protected]; [email protected]
liver lipid accumulation, insulin sensitivity reduction, and persistent inflammation [3]. NAFLD has a variety of pathogenesis including insulin resistance. Under normal conditions, insulin can inhibit lipolysis of white adipose tissue and liver gluconeogenesis, and promote liver lipid synthesis. In the state of insulin resistance, insulin inhibits lipolysis of adipose tissue and the decrease of liver gluconeogenesis, and the promotion of liver lipid synthesis is not affected [3]. After insulin resistance occurs in the body, fatty degeneration of the liver occurs by increasing the de novo synthesis of liver lipid and lipolysis of fatty tissue, and develops towards NASH. Therefore, insulin resistance plays a key role in the development of NAFLD. At present, there is still a lack of drugs for NAFLD clinically [4]. Lifestyle changes an
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