Electrophysiology of the Mitochondrial Apoptosis-Induced Channel, MAC
MAC is distinct from typical ion channels in its huge pore diameter of 4–6 nm and poor ion selectivity. Although it has been identified during intracellular recordings, MAC is typically studied by patch-clamping mitochondria isolated from apoptotic cells.
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Anne H. Delcour Editor
Electrophysiology of Unconventional Channels and Pores
Springer Series in Biophysics 18 Series editor Boris Martinac
For further volumes: http://www.springer.com/series/835
Anne H. Delcour Editor
Electrophysiology of Unconventional Channels and Pores
Editor Anne H. Delcour Department of Biology and Biochemistry University of Houston Houston, TX USA
Series editor Boris Martinac University of New South Wales Victor Chang Cardiac Research Inst. Darlinghurst New South Wales Australia
ISSN 0932-2353 ISSN 1868-2561 (electronic) Springer Series in Biophysics ISBN 978-3-319-20148-1 ISBN 978-3-319-20149-8 (eBook) DOI 10.1007/978-3-319-20149-8 Library of Congress Control Number: 2015954077 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
Electrophysiologists have been fascinated by unconventional channels for a long time. Nature has indeed provided to them a great variety of channels and pores that do not quite fit with the canonical description of ion channels, such as those originally described in excitable cells. When presented with the notion of “ion channel,” most of us will mentally refer to the voltage-dependent sodium or potassium channels of neurons, and their relatives, channels usually found in the plasma membrane of eukaryotic cells, often highly selective for ions and tightly gated by specific stimuli, and typically constructed as bundles of α-helical transmembrane segments delineating a narrow pore. We now know that many pore-forming entities do not follow this mold, and the combination of electrophysiology, biochemistry, and structural biology has revealed a vast array of channel architectures and functional phenotypes. A quick look at a typical scientific program of the Biophysical Societ
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