Electrospun polyacrylonitrile/cellulose acetate/MIL-125/TiO 2 composite nanofibers as an efficient photocatalyst and ant
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ORIGINAL RESEARCH
Electrospun polyacrylonitrile/cellulose acetate/MIL-125/ TiO2 composite nanofibers as an efficient photocatalyst and anticancer drug delivery system Ehsan Bahmani . Hasti Seyyed Zonouzi . Shahnaz Koushkbaghi . Farnoosh Keyvani Hafshejani . Arash Fassadi Chimeh . Mohammad Irani
Received: 9 May 2020 / Accepted: 12 September 2020 Ó Springer Nature B.V. 2020
Abstract In the present study, the various amounts of MIL-125-NH2 metal organic framework (MOF)/ TiO2 nanocomposite were incorporated into the polyacrylonitrile (PAN)/cellulose acetate (CA) (8:2 w/w) nanofibers. The performance of MIL-125-NH2/TiO2 nanocomposite loaded-PAN/CA nanofibers was investigated for the removal of Doxorubicin HCl (DOX) and Cr(VI) during photocatalysis/adsorption method, controlled release of DOX and MCF-7 breast cancer cells death in vitro. The synthesized MIL-125E. Bahmani Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran H. Seyyed Zonouzi Biomedical Engineering Faculty, Science and Research Branch, Islamic Azad University, Tehran, Iran S. Koushkbaghi Science and Research Branch, Islamic Azad University, Yazd, Iran F. Keyvani Hafshejani Department of Chemical Engineering, Amirkabir University of Technology, Tehran, Iran A. Fassadi Chimeh Department of Chemical Engineering, Sciences and Research Branch, Islamic Azad University, Tehran, Iran M. Irani (&) Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran e-mail: [email protected]; [email protected]
NH2 MOF, TiO2, MOF/TiO2 and MOF/TiO2 loadednanofibers were characterized using X-ray diffraction, scanning electron microscopy, Fourier transform infrared, transmission electron microscopy, and Brunaure–Emmet–Teller analysis. The effect of MOF to TiO2 weight ratio, MOF/TiO2 content, pH, contact time, catalyst dosage, and initial concentrations of DOX and Cr(VI) solutions was evaluated on the photocatalytic removal of DOX molecules and Cr(VI) ions from aqueous solutions. The maximum monolayer adsorption capacity of synthesized PAN/CA// MIL-125-NH2/TiO2 nanofibers was found to be 244.5 and 273.3 mg g-1 for DOX and Cr(VI) sorption, respectively. The reusability of nanofibers was also examined after five runs. The sustained release of DOX from PAN/CA/MIL-125-NH2/TiO2 was obtained during 7 days. The maximum MCF-7 cells death percentage was found to be 68% in the presence of PAN/CA/MIL-125-NH2/TiO2 nanofibers. Keywords Polyacrylonitrile/cellulose acetate MIL-125/TiO2 Photocatalysis/adsorption Controlled release MCF-7 breast cancer
Introduction The photocatalytic oxidation method is an efficient method for the removal of heavy metal ions and
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Cellulose
pharmaceutical wastewaters (Irani et al. 2015; Mekasuwandumrong et al. 2019; Shahzad et al. 2019; Dong et al. 2019). Recently, the titanium-based metal organic frame works (MOFs) exhibited the greater advantage for various wastewaters treatment during photocatalytic process in comparison to the neat TiO2 nanoparticles (Zhaohui
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