Cellulose nanofibers electrospun from aqueous conditions
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ORIGINAL RESEARCH
Cellulose nanofibers electrospun from aqueous conditions Hui Zhang . Yan Liu . Sisi Cui . Yifa Zhou . Junli Hu Yichun Liu
. Jiangang Ma .
Received: 12 January 2020 / Accepted: 23 July 2020 Ó Springer Nature B.V. 2020
Abstract Electrospun cellulose nanofibers are promising biomaterials but are suffering from the use of unfavorable organic solvents during the electrospinning process. In this manuscript, we used the periodate oxidation—adipic acid dihydrazide crosslinking strategy to fabricate electrospun cellulose nanofibers. Periodate oxidation of cellulose generated water soluble aldehyde cellulose, which thus allowed for the electrospinning in aqueous solution and avoided the use of unfavorable organic solvents. The
following crosslinking with adipic acid dihydrazide made the nanofibers water resistant. The results show that the prepared cellulose nanofiber mats show moderate wet mechanical strength around 1 MPa, are able to absorb water equal to 30 times of their own weight, can degrade gradually by hydrolysis, and are cytocompatible. These cellulose nanofibers are expected to find applications in biomedical fields such as wound healing and tissue regeneration.
H. Zhang Y. Liu J. Hu J. Ma (&) Y. Liu Key Laboratory of UV-Emitting Materials and Technology (Northeast Normal University), Ministry of Education, Changchun 130024, Jilin, China e-mail: [email protected] S. Cui Y. Zhou School of Life Sciences, Northeast Normal University, Changchun 130024, Jilin, China J. Hu (&) J. Ma Y. Liu National Demonstration Centre for Experimental Physics Education, Northeast Normal University, Changchun 130024, Jilin, China e-mail: [email protected]
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Cellulose
Graphic abstract
Keywords Cellulose Nanofiber Electrospinning Crosslinking
Introduction Cellulose, a linear homopolysaccharide composed of b-1,4-linked D-glucopyranose, is the most abundant biomass in nature and the most attractive natural materials in human life (Mora´n et al. 2008). Cellulose and its derivatives have a long application history in medical fields, from the very traditional cotton gauzes to the modern hemostatic powders and wound dressings (Cullen et al. 2002; Hart et al. 2002; Gabriel et al. 2020; Wu et al. 2017). Nanocellulose refers to cellulose materials with one or more dimensions in nanoscale. There are different types of nanocellulose, cellulose whisker, micro fibrillated cellulose, bacterial cellulose, and electrospun cellulose nanofibers (Klemm et al. 2011). Comparing with the other three types of nanocellulose, electrospun cellulose nanofibers have unique structural advantages for biomedical applications. Nanofibers of various surface morphologies, structures, or orientations were able to be fabricated by tuning the experimental setup and parameters during the electrospinning process, to satisfy the needs of various biomedical applications (Huang et al. 2003; Schiffman and Schauer 2008). The unique nonwoven nanofibrous structure generated by electros
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