Elevated expression of MAC30 predicts lymph node metastasis and unfavorable prognosis in patients with epithelial ovaria
- PDF / 740,857 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 73 Downloads / 196 Views
ORIGINAL PAPER
Elevated expression of MAC30 predicts lymph node metastasis and unfavorable prognosis in patients with epithelial ovarian cancer Shanshan Yang • Huiyan Li • Yunduo Liu • Xiaoming Ning • Fanling Meng • Min Xiao • Deying Wang • Ge Lou • Yunyan Zhang
Received: 21 July 2012 / Accepted: 23 July 2012 Ó Springer Science+Business Media New York 2012
Abstract Meningioma-associated protein (MAC30), first described to be overexpressed in meningiomas, exhibits altered expression in certain human tumors. The definite role of MAC30 is not clear now, and few studies have documented the value of MAC30 in epithelial ovarian cancer (EOC). The aim of this study was to investigate the expression of MAC30 in EOC and to evaluate its clinical significance in patients with EOC. A total of 266 patients with EOC who undergone complete cytoreductive surgery from November 2003 to September 2006 were eligible for this study. The expression of MAC30 in epithelial ovarian tumor tissues was examined immunohistochemically. High expression of MAC30 was observed in 66.17 % of EOC. Shanshan Yang and Huiyan Li contributed equally to this manuscript. S. Yang Y. Liu F. Meng G. Lou (&) Y. Zhang (&) Department of Gynecology, The Affiliated Tumor Hospital of Harbin Medical University, Baojian Road 6, Nangang District, Harbin 150081, China e-mail: [email protected] Y. Zhang e-mail: [email protected] H. Li Department of Radiotherapy, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China X. Ning Department of Pathology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China M. Xiao Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China D. Wang Department of Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
The high MAC30 expression group had more advanced stages, poorer histological grade, lymph node metastasis, and recurrence than those with low MAC30 expression. Moreover, the presence of lymph node metastasis was significantly associated with MAC30 expression (OR 2.888, 95 % CI 1.428–5.838, P = 0.003). In addition, it was also shown that high MAC30 expression significantly correlated with poorer overall survival and progression-free survival (both P \ 0.001). Multivariate Cox regression analysis revealed that MAC30 expression status was an independent prognostic factor for both overall survival and progression-free survival (P = 0.001 and P = 0.002, respectively) of patients with EOC. Our study provides evidence that patients with expression of MAC30 in EOC have high malignant potential, and MAC30 may serve as a new molecular marker to predict the lymph node metastasis and prognosis of patients with EOC in the clinic. Keywords Epithelial ovarian cancer MAC30 Immunohistochemistry Prognosis Lymph node metastasis
Introduction Epithelial ovarian cancer (EOC) is a common gynecological malignancy that is associated with an unfavorable prognosis, and it is the fifth leading cause of death in women worldwid
Data Loading...
