Elevated high-sensitivity troponin T levels at 1-year follow-up are associated with increased long-term mortality after
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ORIGINAL PAPER
Elevated high‑sensitivity troponin T levels at 1‑year follow‑up are associated with increased long‑term mortality after TAVR Hatim Seoudy1,2 · Moritz Lambers3 · Vincent Winkler1 · Linnea Dudlik1 · Sandra Freitag‑Wolf4 · Johanne Frank1,2 · Christian Kuhn1,2 · Ashraf Yusuf Rangrez1,2 · Thomas Puehler2,5 · Georg Lutter2,5 · Peter Bramlage6 · Norbert Frey1,2 · Derk Frank1,2 Received: 20 August 2020 / Accepted: 5 October 2020 © The Author(s) 2020
Abstract Background Elevated pre-procedural high-sensitivity troponin T (hs-TnT) levels predict adverse outcomes in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). It is unknown whether elevated troponin levels still provide prognostic information during follow-up after successful TAVR. We evaluated the long-term implications of elevated hs-TnT levels found at 1-year post-TAVR. Methods and results The study included 349 patients who underwent TAVR for severe AS from 2010–2019 and for whom 1-year hs-TnT levels were available. Any required percutaneous coronary interventions were performed > 1 week before TAVR. The primary endpoint was survival time starting at 1-year post-TAVR. Optimal hs-TnT cutoff for stratifying risk, identified by ROC analysis, was 39.4 pg/mL. 292 patients had hs-TnT
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