Glucose-Lipid Metabolism in Obesity with Elevated Prolactin Levels and Alteration of Prolactin Levels After Laparoscopic
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ORIGINAL CONTRIBUTIONS
Glucose-Lipid Metabolism in Obesity with Elevated Prolactin Levels and Alteration of Prolactin Levels After Laparoscopic Sleeve Gastrectomy Xingchun Wang 1,2
&
Bingwei Ma 1 & Guifang Li 1 & Chunjun Sheng 1,2 & Peng Yang 1,2 & Jingyang Gao 1 & Shen Qu 1,2
Received: 6 November 2019 / Revised: 22 May 2020 / Accepted: 4 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose We investigated the differences in metabolism between obesity with or without increased prolactin (PRL) and the change in PRL after laparoscopic sleeve gastrectomy (LSG). Methods Patients were divided into two groups: obesity with normal PRL (NP, n = 123) and high PRL (HP, n = 108). Glucoselipid metabolism and inflammation were measured. A total of 115 patients with obesity (NP, n = 64; HP, n = 51) underwent LSG were recruited, and PRL was measured at 12 months after LSG. Results (1) Blood glucose (BG), total cholesterol (TCH), LDL, triglyceride, and TNF-α were lower in the HP than in the NP group in the cross-sectional study (all P < 0.05). (2) PRL was negatively associated with neck circumference, waist-to-hip ratio, systolic blood pressure, heart rate, basal metabolism rate (BMR), ALP, TCH, and LDL in all subjects. PRL levels were positively associated with weight, HC, and BMR in males but were negatively associated with ALT, AST, ALP, BG 30 min, BG 60 min, FFA, and TCH in females (all P < 0.05). (3) Regression analysis showed that PRL negatively correlated with ALP and LDL-C in the whole baseline (β = − 0.051, P = 0.002; β = − 1.372, P = 0.033). PRL was a negative factor for ALP in females and a positive factor for BMR2 in males (β = − 0.099, P = 0.041; β = 0.005, P = 0.006). (4) PRL decreased in the HP group and increased in the NP group at 12 months post-operation (all P < 0.05). Increased PRL was associated with a change in TCH in the NP group (P < 0.05). Conclusion Increased PRL resulted in improved glucose-lipid metabolism and chronic low-grade inflammation. LSG led to increased PRL in NP and decreased PRL in HP. Improved lipid was associated with increased PRL in NP after surgery. Clinical Trial Registration Number ChiCTR-OCS-12002381. Keywords Obesity . Prolactin . Sleeve gastrectomy . Glucose-lipid metabolism
Introduction Obesity is a growing global issue that increases the risk of individuals developing cardiovascular disease, non-alcoholic fatty liver disease (NAFLD), and diabetes. The pituitary hormone prolactin (PRL) is a multifunctional hormone secreted
Xingchun Wang, Bingwei Ma, and Guifang Li are co-first authors. * Shen Qu [email protected] 1
Department of Endocrinology and Metabolism, School of Medicine, Shanghai Tenth People’s Hospital of Tongji University, No. 301 Middle Yanchang Road, Shanghai 200072, China
2
Thyroid Research Center of Shanghai, Shanghai 200072, China
by the anterior pituitary gland. Hyperprolactinemia has been implicated in the pathogenesis of obesity and is associated with body weight. Recent studies have shown that PRL hormone se
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