Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with impro
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ORIGINAL ARTICLE
Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics Salaheldin Ahmed1,2 · Abdulla Ahmed1,2 · Habib Bouzina1,2 · Jakob Lundgren1,2 · Göran Rådegran1,2 Received: 15 January 2020 / Accepted: 26 June 2020 © The Author(s) 2020
Abstract Background The prevalence of heart failure (HF) is rising with ageing population and constitutes a major health problem globally. A common complication of HF is pulmonary hypertension (PH) which negatively impacts survival. A pathophysiological association between HF and PH with tumorigenic processes has been suggested. We aimed to identify the plasma levels of, and the association between tumour-related proteins and hemodynamic improvements in patients with HF and PH due to left heart disease (LHD) before and 1-year after heart transplantation (HT). Methods Forty-eight tumour-related proteins were measured with proximity extension assay in plasma from 20 controls and 26 HF patients before and 1-year after HT. Patients’ hemodynamics were measured with right heart catheterization. Results Out of 48 proteins, specifically, plasma levels of endocan and brother of CDO (BOC) were elevated in end-stage HF patients compared to controls (p
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