Emerging Therapies in Periodontics
This book equips dental care providers with a thorough understanding of the emerging therapies that promise to revolutionize the clinical management of periodontal diseases. Existing therapies targeted to the oral microbiome alone often fail to provide fa
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Emerging Therapies in Periodontics
Sinem Esra Sahingur Editor
Emerging Therapies in Periodontics
Editor Sinem Esra Sahingur School of Dental Medicine, Department of Periodontics University of Pennsylvania Philadelphia, PA USA
ISBN 978-3-030-42989-8 ISBN 978-3-030-42990-4 (eBook) https://doi.org/10.1007/978-3-030-42990-4 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
Part I Periodontal Therapies Targeting Host Immune and Inflammatory System 1 Evolving Paradigms in the Pathogenesis and Management of Periodontitis�������������������������������������������������� 3 Sinem Esra Sahingur 2 Complement C3 as a Target of Host Modulation in Periodontitis �������������������������������������������������������������������������������� 13 George Hajishengallis, Tetsuhiro Kajikawa, Evlambia Hajishengallis, Tomoki Maekawa, Xiaofei Li, George N. Belibasakis, Nagihan Bostanci, Dimitrios C. Mastellos, Despina Yancopoulou, Hatice Hasturk, and John D. Lambris 3 Resolvins in Periodontal Tissue Homeostasis (Emerging Therapies)���������������������������������������������������������������������� 31 Audrey Rakian, Rubie Rakian, Nada Alshehri, and Thomas E. Van Dyke 4 Salicylic Acid Polymers in Periodontal Tissue Healing���������������� 43 Dana Graves, Yue Cao, Paulo Coelho, Lukasz Witek, and Kathryn Uhrich 5 Targeting MAPK/MKP Signaling as a Therapeutic Axis in Periodontal Disease ������������������������������������������������������������ 55 Keith L. Kirkwood 6 The IL-17/Th17 Axis as a Therapeutic Target in Periodontitis �������������������������������������������������������������������������������� 73 Nicolas Dutzan, L
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