Lung Cancer Prevention, Management, and Emerging Therapies
This comprehensive resource provides authoritative knowledge of the most up-to-date prevention and treatment strategies for thoracic malignancies. Established and investigational therapies are placed in the context of tumor biology for a full understandin
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David J. Stewart Editor
Lung Cancer
Current Clinical Oncology Maurie Markman, MD, Series Editor
For other titles published in this series, go to www.springer.com/series/7631
Lung Cancer Prevention, Management, and Emerging Therapies
Edited by
David J. Stewart, md, frcpc Professor and Deputy Chair, Department of Thoracic Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
Editor David J. Stewart, MD, FRCPC Professor and Deputy Chair Department of Thoracic Head and Neck Medical Oncology Division of Cancer Medicine The University of Texas M.D. Anderson Cancer Center Houston, TX USA [email protected]
ISBN 978-1-60761-523-1 e-ISBN 978-1-60761-524-8● DOI 10.1007/978-1-60761-524-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010921199 © Humana Press, a part of Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press, a part of Springer Science+Business Media (www.springer.com)
This book is dedicated to Lesley, Megan, Adam, Andrew, Jenika, Grayson and Cameron whose love gives purpose to my life and work, and whose support, understanding and patience make all things possible.
Preface
Defining the Lung Cancer Problem Lung cancer is the leading cause of cancer death in the world.1 It kills almost as many Americans as cancers of the breast, prostate, colon, rectum, pancreas, and kidney combined, and accounts for 28.6% of all US cancer deaths.2 With an increase in the 5-year relative survival rate from 13% to only 16% in the more than 30 years from 1974 to the present,2 it will take us another 840 years to eradicate lung cancer deaths if we do not improve the current rate of progress. As discussed in this text, lung cancer prevention has received substantial attention. The decrease in smoking in recent decades has helped, but smoking is not the only problem. Lung cancer in people who have n
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