Endoscopic resection of T1 colorectal cancer prior to surgery does not affect surgical adverse events and recurrence
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and Other Interventional Techniques
Endoscopic resection of T1 colorectal cancer prior to surgery does not affect surgical adverse events and recurrence Yusuke Yamaoka1 · Kenichiro Imai2 · Akio Shiomi1 · Hiroyasu Kagawa1 · Hitoshi Hino1 · Yushi Yamakawa1 · Tomohiro Yamaguchi1,3 · Yusuke Kinugasa1,4 · Yoshihiro Kishida2 · Sayo Ito2 · Kinichi Hotta2 · Toru Imai5 Received: 31 May 2019 / Accepted: 28 November 2019 © Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Background Although a “no-touch isolation” technique is used in colorectal cancer surgery to reduce the risk of metastatic induction, endoscopic resection (ER) prior to surgery may work against this aim. This study evaluated the effects of initial ER on short- and long-term outcomes in T1 colorectal cancer. Methods This retrospective cohort study enrolled patients with pathological T1 colorectal cancer who underwent colorectal surgical resection at a Japanese tertiary cancer center between 2002 and 2012. A total of 548 eligible patients were divided into two groups: patients initially treated using surgical resection with lymph node dissection (LND) (primary group, n = 304) and patients treated using initial ER and additional surgical resection with LND (secondary group, n = 244). The inverse probability of treatment weighting (IPTW) method based on propensity score was used to compare postoperative complications and long-term recurrence. Results The incidence of postoperative complications with Clavien–Dindo classification grade ≥ II was 10.9% and 7.4% in the primary and secondary groups, respectively (p = 0.16). Multivariate analysis with a logistic proportional hazard regression model using IPTW revealed no significant differences in postoperative complications between the two groups (p = 0.79). During a median follow-up after surgery of 61.4 months, recurrence was observed in 3 (1.0%) and 8 (3.3%) patients, respectively (p = 0.06). Multivariate analysis with a Cox proportional hazard regression model using IPTW revealed no significant differences in recurrence between the two groups (p = 0.07). Conclusion Our results suggest no significant adverse effects of initial ER prior to surgery on surgical complications and long-term recurrence in T1 colorectal cancer. Keywords T1 colorectal cancer · Endoscopic resection · Surgery · Surgical outcome · Recurrence · Propensity score
* Kenichiro Imai [email protected] 1
Division of Colon and Rectal Surgery, Shizuoka Cancer Center, Sunto‑gun, Japan
2
Division of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi‑cho, Sunto‑gun, Shizuoka 411‑8777, Japan
3
Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
4
Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan
5
Clinical Research Promotion Unit, Shizuoka Cancer Center, Sunto‑gun, Japan
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of
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