Postoperative Adverse Events are Associated with Oncologic Recurrence Following Curative-intent Resection for Lung Cance
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LUNG CANCER SURGERY
Postoperative Adverse Events are Associated with Oncologic Recurrence Following Curative‑intent Resection for Lung Cancer Gowing Stephen5 · Baker Laura1 · Tran Alexandre1 · Zhang Zach4 · Ahn Hilalion4 · Ivanovic Jelena2,3 · Anstee Caitlin5 · Grigor Emma4 · Gilbert Sebastien5 · Maziak Donna Elizabeth2,3,4,5 · Shamji Farid5 · Sundaresan Sudhir R3,5 · Villeneuve Patrick James5 · Seely Andrew JE2,3,4,5 Received: 15 June 2020 / Accepted: 25 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Up to 50% of patients suffer short-term postoperative adverse events (AEs) and metastatic recurrence in the long-term following curative-intent lung cancer resection. The association between AEs, particularly infectious in nature, and disease recurrence is controversial. We sought to evaluate the association of postoperative AEs on risk of developing recurrence and recurrence-free survival (RFS) following curative-intent lung resection surgery. Methods All lung cancer resections at a single institution (January 2008–July 2015) were included, with prospective collection of AEs using the Thoracic Morbidity & Mortality System. Cox proportional hazards models were used to estimate the effect of AEs on recurrence, with results presented as hazard ratio (HR) with 95% confidence interval (CI). An a priori, clinically driven approach to predictor variable selection was used. Kaplan–Meier curves were used examine the relationship between AE and RFS. p
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