Endothelial Mechanisms of Vasomotor Control With special Reference t
In recent years, we have witnessed a rapid expansion of our knowledge regarding the role of the endothelium in the control of vascular tone (and organ perfusion) in health and disease. Physiology, pharmacology, and molecular biology have uncovered a wealt
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H. Drexler, A.M. Zeiher, E. Bassenge, H. Just (eds.)
Endothelial Mechanisms of Vasomotor Control With special Reference to the Coronary Circulation
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Steinkopff Verlag Darmstadt Springer-Verlag New York
The editors: Dr. H. Drexler, Dr. A. Zeiher, Prof. Dr. H. Just Klinikum der Albert-Ludwigs-UniversiHit Abteilung Innere Medizin Hugstetter StraBe 55 7800 Freiburg Prof. Dr. E. Bassenge Institut fUr angewandte Physiologie Hermann-Herder-StraBe 7 7800 Freiburg
Die Deutsche Bibliothek - CIP-Einheitsaufnahme Endothelial mechanisms of vasomotor control: with special reference to the coronary circulation/ H. Drexler ... (ed.). - Darmstadt: Steinkopff; New York: Springer, 1991 (Supplement to Basic research in cardiology; Vo!. 86, Supp!. 2) ISBN-13: 978-3-642-72463-3 e-ISBN-13: 978-3-642-72461-9 DOT: 10.1007/978-3-642-72461-9 NE: Drexler, Helmut [Hrsg.]; Basic research in cardiology/Supplement Basic Res. Cardio!. ISSN 0300-8428 Indexed in Current Contents. This work is subject to copyright. All rights are reserved, wether the hole or part of the material is concerned, specifically the right of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24,1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyrigth Law. Copyright © 1991 by Dr. Dietrich SteinkopffVerlag GmbH & Co. KG, Darmstadt Medical editor: Sabine Muller - English editor: James C. Willis - Production: Heinz J. Schafer Softcover reprint of the hardcover 1st edition 1991 The use of registered names, trademarks, etc. in this puclication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper
Preface
In recent years, we have witnessed a rapid expansion of our knowledge regarding the role of the endothelium in the control of vascular tone (and organ perfusion) in health and disease. Physiology, pharmacology, and molecular biology have uncovered a wealth of information on structure and function of this heretofore largely neglected "organ". Clinical medicine is now called upon to define the clinical significance of these observations that imply the mechanisms of blood coagulation, e.g., the interaction of thrombocytes with the endothelium, vasomotor control, and specifically, the regulation of smooth muscle tone with consequences for vascular resistance and conductance and organ blood flow. Finally, metabolism of lipids with the everlasting problem of atherosclerosis is an important aspect. In a second step, implications regarding the improvement of current therapeutic concepts, as well as the development of new modalities of pharmacotherapy will have to be discussed. The topic addressed by the 1990 Gargellen Conference: Endotheli
