Engineering of functionalized carbon nano-onions reinforced nanocomposites: Fabrication, biocompatibility, and mechanica

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Engineering of functionalized carbon nano-onions reinforced nanocomposites: Fabrication, biocompatibility, and mechanical properties Narsimha Mamidi1,a) , Marcelo Renato Martínez Gamero1, Ramiro Manuel Velasco Delgadillo1, Javier Villela Castrejón1, Alex Elías Zúníga1 1

Department of Chemistry and Nanotechnology, Tecnologico de Monterrey, School of Engineering and Science, Monterrey, Nuevo Leon 64849, Mexico Address all correspondence to this author. e-mail: [email protected] This paper has been selected as an Invited Feature Paper. a)

Received: 21 August 2019; accepted: 7 January 2020

Poly 4-mercaptophenyl methacrylate-carbon nano-onions ((PMPMA-CNOs = f-CNOs) were reinforced with polycaprolactone (PCL) to produce PCL/f-CNO nanocomposites using probe sonication. The physicochemical properties of nanocomposites were systematically studied to analyze cell viability and proliferation. In vitro cytotoxicity of PCL/f-CNO nanocomposites was measured with osteoblast cells, and improved cell viability was observed. The cytotoxicity of f-CNOs to osteoblasts was dose-dependent, and PCL/f-CNO (0.5 wt%) nanocomposites showed more than 90% of viability as compared to pristine PCL. Similarly, PCL/f-CNO (0.5 wt%) nanocomposites showed substantial enhancement in mechanical properties. The yield strength, tensile strength, Young modulus, elastic modulus, and fracture toughness were also upgraded at high content of f-CNOs (0.5 wt%). The concentration of f-CNOs considerably influenced the strengthening of PCL/f-CNO nanocomposites, which shows its degree of colloidal dispersion stability and extent of polymer wrapping within the PCL matrix. Nevertheless, these nontoxic PCL/f-CNO nanocomposites can be used as promising biomaterials for orthopedic applications.

Narsimha Mamidi

Dr. Narsimha Mamidi received his B.Sc. in chemistry from the Osmania University, in 2006 and M.Sc. in organic chemistry from Kakatiya University, Warangal, India, in 2008. He then moved to the Indian Institute of Technology Guwahati, India, for Ph.D. (Organic Chemistry) in 2009. During his Ph.D., he designed and synthesized various novel biological organic molecules and investigated their interactions with protein kinase C (PKC). In October 2014, he received Ph.D. from the Indian Institute of Technology Guwahati, India. Dr. Mamidi has received 2014-Eli-Lilly Outstanding Thesis Award for his Ph.D. research. He then moved to the Indian Institute of Technology Mandi, India, where from 09/2014 to 09/2015 he was a postdoctoral fellow. During his postdoc, he developed novel photoresist and bioresist materials and investigated their lithography studies to achieve below 16-nm size patterning. Currently, Dr. Mamidi is working as a postdoctoral researcher at the school of engineering and science, Tecnologico de Monterrey, Mexico. His current research interest is focused on the rational design and development of bio/nanomaterials for biomedical, catalysis, sensing, and energy storage applications.

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